The investigational fungal Cyp51 inhibitor VT-1129 demonstrates potent in vitro activity against cryptococcus neoformans and cryptococcus gattii

Shawn R. Lockhart; Annette W. Fothergill; Naureen Iqbal; Carol B. Bolden; Nina T. Grossman; Edward P. Garvey; Stephen R. Brand; William J. Hoekstra; Robert J. Schotzinger; Elizabeth Ottinger; Thomas F. Patterson; Nathan P. Wiederhold

doi:10.1128/AAC.02770-15

The investigational fungal Cyp51 inhibitor VT-1129 demonstrates potent in vitro activity against cryptococcus neoformans and cryptococcus gattii

Shawn R. Lockhart
, Annette W. Fothergill
, Naureen Iqbal
, Carol B. Bolden
, Nina T. Grossman
, Edward P. Garvey
, Stephen R. Brand
, William J. Hoekstra
, Robert J. Schotzinger
, Elizabeth Ottinger
, Thomas F. Patterson
, Nathan P. Wiederhold

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

The in vitro activities of the novel fungal Cyp51 inhibitor VT-1129 were evaluated against a large panel of Cryptococcus neoformans and Cryptococcus gattii isolates. VT-1129 demonstrated potent activities against both Cryptococcus species as demonstrated by low MIC₅₀and MIC₉₀values. For C. gattii, the in vitro potency was maintained against all genotypes. In addition, significantly lower geometric mean MICs were observed for VT-1129 than for fluconazole against C. neoformans, including isolates with reduced fluconazole susceptibility.

Original language	English (US)
Pages (from-to)	2528-2531
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	60
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02770-15
State	Published - Apr 2016

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/AAC.02770-15

Cite this

Lockhart, S. R., Fothergill, A. W., Iqbal, N., Bolden, C. B., Grossman, N. T., Garvey, E. P., Brand, S. R., Hoekstra, W. J., Schotzinger, R. J., Ottinger, E., Patterson, T. F., & Wiederhold, N. P. (2016). The investigational fungal Cyp51 inhibitor VT-1129 demonstrates potent in vitro activity against cryptococcus neoformans and cryptococcus gattii. Antimicrobial agents and chemotherapy, 60(4), 2528-2531. https://doi.org/10.1128/AAC.02770-15

Lockhart, SR, Fothergill, AW, Iqbal, N, Bolden, CB, Grossman, NT, Garvey, EP, Brand, SR, Hoekstra, WJ, Schotzinger, RJ, Ottinger, E, Patterson, TF & Wiederhold, NP 2016, 'The investigational fungal Cyp51 inhibitor VT-1129 demonstrates potent in vitro activity against cryptococcus neoformans and cryptococcus gattii', Antimicrobial agents and chemotherapy, vol. 60, no. 4, pp. 2528-2531. https://doi.org/10.1128/AAC.02770-15

@article{dd155ac633bf4cfd95de184b124860d0,

title = "The investigational fungal Cyp51 inhibitor VT-1129 demonstrates potent in vitro activity against cryptococcus neoformans and cryptococcus gattii",

abstract = "The in vitro activities of the novel fungal Cyp51 inhibitor VT-1129 were evaluated against a large panel of Cryptococcus neoformans and Cryptococcus gattii isolates. VT-1129 demonstrated potent activities against both Cryptococcus species as demonstrated by low MIC50and MIC90values. For C. gattii, the in vitro potency was maintained against all genotypes. In addition, significantly lower geometric mean MICs were observed for VT-1129 than for fluconazole against C. neoformans, including isolates with reduced fluconazole susceptibility.",

author = "Lockhart, \{Shawn R.\} and Fothergill, \{Annette W.\} and Naureen Iqbal and Bolden, \{Carol B.\} and Grossman, \{Nina T.\} and Garvey, \{Edward P.\} and Brand, \{Stephen R.\} and Hoekstra, \{William J.\} and Schotzinger, \{Robert J.\} and Elizabeth Ottinger and Patterson, \{Thomas F.\} and Wiederhold, \{Nathan P.\}",

year = "2016",

month = apr,

doi = "10.1128/AAC.02770-15",

language = "English (US)",

volume = "60",

pages = "2528--2531",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "4",

}

TY - JOUR

T1 - The investigational fungal Cyp51 inhibitor VT-1129 demonstrates potent in vitro activity against cryptococcus neoformans and cryptococcus gattii

AU - Lockhart, Shawn R.

AU - Fothergill, Annette W.

AU - Iqbal, Naureen

AU - Bolden, Carol B.

AU - Grossman, Nina T.

AU - Garvey, Edward P.

AU - Brand, Stephen R.

AU - Hoekstra, William J.

AU - Schotzinger, Robert J.

AU - Ottinger, Elizabeth

AU - Patterson, Thomas F.

AU - Wiederhold, Nathan P.

PY - 2016/4

Y1 - 2016/4

N2 - The in vitro activities of the novel fungal Cyp51 inhibitor VT-1129 were evaluated against a large panel of Cryptococcus neoformans and Cryptococcus gattii isolates. VT-1129 demonstrated potent activities against both Cryptococcus species as demonstrated by low MIC50and MIC90values. For C. gattii, the in vitro potency was maintained against all genotypes. In addition, significantly lower geometric mean MICs were observed for VT-1129 than for fluconazole against C. neoformans, including isolates with reduced fluconazole susceptibility.

AB - The in vitro activities of the novel fungal Cyp51 inhibitor VT-1129 were evaluated against a large panel of Cryptococcus neoformans and Cryptococcus gattii isolates. VT-1129 demonstrated potent activities against both Cryptococcus species as demonstrated by low MIC50and MIC90values. For C. gattii, the in vitro potency was maintained against all genotypes. In addition, significantly lower geometric mean MICs were observed for VT-1129 than for fluconazole against C. neoformans, including isolates with reduced fluconazole susceptibility.

UR - https://www.scopus.com/pages/publications/84963717381

UR - https://www.scopus.com/pages/publications/84963717381#tab=citedBy

U2 - 10.1128/AAC.02770-15

DO - 10.1128/AAC.02770-15

M3 - Article

C2 - 26787697

AN - SCOPUS:84963717381

SN - 0066-4804

VL - 60

SP - 2528

EP - 2531

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 4

ER -

The investigational fungal Cyp51 inhibitor VT-1129 demonstrates potent in vitro activity against cryptococcus neoformans and cryptococcus gattii

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this