The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans

Nathan P. Wiederhold; Laura K. Najvar; Annette W. Fothergill; Dora I. McCarthy; Rosie Bocanegra; Marcos Olivo; William R. Kirkpatrick; Michael P. Everson; Frederick P. Duncanson; Thomas F. Pattersona

doi:10.1128/AAC.03944-14

The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans

Nathan P. Wiederhold
, Laura K. Najvar
, Annette W. Fothergill
, Dora I. McCarthy
, Rosie Bocanegra
, Marcos Olivo
, William R. Kirkpatrick
, Michael P. Everson
, Frederick P. Duncanson
, Thomas F. Pattersona

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandinresistant C. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.

Original language	English (US)
Pages (from-to)	690-692
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	59
Issue number	1
DOIs	https://doi.org/10.1128/AAC.03944-14
State	Published - Jan 1 2015

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Wiederhold, N. P., Najvar, L. K., Fothergill, A. W., McCarthy, D. I., Bocanegra, R., Olivo, M., Kirkpatrick, W. R., Everson, M. P., Duncanson, F. P., & Pattersona, T. F. (2015). The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans. Antimicrobial agents and chemotherapy, 59(1), 690-692. https://doi.org/10.1128/AAC.03944-14

Wiederhold, NP, Najvar, LK, Fothergill, AW, McCarthy, DI, Bocanegra, R, Olivo, M, Kirkpatrick, WR, Everson, MP, Duncanson, FP & Pattersona, TF 2015, 'The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans', Antimicrobial agents and chemotherapy, vol. 59, no. 1, pp. 690-692. https://doi.org/10.1128/AAC.03944-14

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title = "The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans",

abstract = "The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandinresistant C. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.",

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AU - Wiederhold, Nathan P.

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AU - McCarthy, Dora I.

AU - Bocanegra, Rosie

AU - Olivo, Marcos

AU - Kirkpatrick, William R.

AU - Everson, Michael P.

AU - Duncanson, Frederick P.

AU - Pattersona, Thomas F.

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AB - The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandinresistant C. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.

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The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans

Abstract

ASJC Scopus subject areas

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