The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans

Nathan Wiederhold, Laura K. Najvar, Annette W. Fothergill, Dora I. McCarthy, Rosie Bocanegra, Marcos Olivo, William R. Kirkpatrick, Michael P. Everson, Frederick P. Duncanson, Thomas F Patterson

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandinresistant C. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.

Original languageEnglish (US)
Pages (from-to)690-692
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number1
DOIs
StatePublished - Jan 1 2015

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Invasive Candidiasis
Candida albicans
caspofungin
Echinocandins
Acyltransferases
Inositol
Body Weight
3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine
Infection
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans. / Wiederhold, Nathan; Najvar, Laura K.; Fothergill, Annette W.; McCarthy, Dora I.; Bocanegra, Rosie; Olivo, Marcos; Kirkpatrick, William R.; Everson, Michael P.; Duncanson, Frederick P.; Patterson, Thomas F.

In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 1, 01.01.2015, p. 690-692.

Research output: Contribution to journalArticle

Wiederhold, Nathan ; Najvar, Laura K. ; Fothergill, Annette W. ; McCarthy, Dora I. ; Bocanegra, Rosie ; Olivo, Marcos ; Kirkpatrick, William R. ; Everson, Michael P. ; Duncanson, Frederick P. ; Patterson, Thomas F. / The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans. In: Antimicrobial Agents and Chemotherapy. 2015 ; Vol. 59, No. 1. pp. 690-692.
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