The intracellular distribution and secretion of endopeptidases 24.15 (EC 3.4.24.15) and 24.16 (EC 3.4.24.16)

Emer S. Ferro, Flávia R. Carreño, Camila Goñi, Paula A.G. Garrido, Alessander O. Guimarães, Leandro M. Castro, Vitor Oliveira, Maurício C. Araujo, Vanessa Rioli, Marcelo D. Gomes, José Domingues Fontenele-Neto, Stephen Hyslop

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Endopeptidase 24.15 (EC 3.4.24.15; EP24.15) and endopeptidase 24.16 (EC 3.4.24.16; EP24.16) are enzymes involved in general peptide metabolism in mammalian cells and tissues. This review will focus on morphological and biochemical aspects related to the subcellular distribution and secretion of these homologous enzymes in the central nervous system. These are important issues for a better understanding of the functions of EP24.15 and EP24.16 within neuroendocrine systems.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalProtein and Peptide Letters
Volume11
Issue number5
DOIs
StatePublished - Oct 2004
Externally publishedYes

Keywords

  • Endopeptidase
  • Exocytosis
  • Fusion pore
  • Neurolysin
  • Peptide metabolism
  • Thimet- oligopeptidase
  • Unconventional secretion

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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