The Intersection of Cellular and Systemic Metabolism: Metabolic Syndrome in Systemic Lupus Erythematosus

Morgan Terrell, Laurence Morel

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

A high prevalence of metabolic syndrome (MetS) has been reported in multiple cohorts of systemic lupus erythematosus (SLE) patients, most likely as one of the consequences of autoimmune pathogenesis. Although MetS has been associated with inflammation, its consequences on the lupus immune system and on disease manifestations are largely unknown. The metabolism of immune cells is altered and overactivated in mouse models as well as in patients with SLE, and several metabolic inhibitors have shown therapeutic benefits. Here we review recent studies reporting these findings, as well as the effect of dietary interventions in clinical and preclinical studies of SLE. We also explore potential causal links between systemic and immunometabolism in the context of lupus, and the knowledge gap that needs to be addressed.

Original languageEnglish (US)
Article numberbqac067
JournalEndocrinology (United States)
Volume163
Issue number7
DOIs
StatePublished - Jul 1 2022
Externally publishedYes

Keywords

  • autoimmunity
  • immunometabolism
  • lupus
  • systemic metabolism

ASJC Scopus subject areas

  • Endocrinology

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