TY - JOUR
T1 - The inhibition of gastric mucosal injury by Punica granatum L. (pomegranate) methanolic extract
AU - Ajaikumar, K. B.
AU - Asheef, M.
AU - Babu, B. H.
AU - Padikkala, J.
PY - 2005/1/4
Y1 - 2005/1/4
N2 - Administration of 70% methanolic extract of Punica granatum fruit rind (250 mg/kg and 500 mg/kg) shows a percentage of inhibition in 22.37, 74.21 and 21.95, 63.41 in aspirin- and ethanol-induced gastric ulceration, respectively. In treated groups of animals, the in vivo antioxidant levels such as superoxide dismutase (SOD), catalase, glutathione (GSH) and glutathione peroxidase (GPx) levels were increased and found more or less equal to the normal values. The tissue lipid peroxidation level was found to be decreasing in treated groups of animals as compared to the control group. The histopathological examination of the stomach of the ulcerated animals shows severe erosion of gastric mucosa, sub-mucosal edema and neutrophil infiltration. All of these symptoms were found to be normal in treated groups. In general, the results of the present investigation revealed the gastroprotective activity of the extract through antioxidant mechanism.
AB - Administration of 70% methanolic extract of Punica granatum fruit rind (250 mg/kg and 500 mg/kg) shows a percentage of inhibition in 22.37, 74.21 and 21.95, 63.41 in aspirin- and ethanol-induced gastric ulceration, respectively. In treated groups of animals, the in vivo antioxidant levels such as superoxide dismutase (SOD), catalase, glutathione (GSH) and glutathione peroxidase (GPx) levels were increased and found more or less equal to the normal values. The tissue lipid peroxidation level was found to be decreasing in treated groups of animals as compared to the control group. The histopathological examination of the stomach of the ulcerated animals shows severe erosion of gastric mucosa, sub-mucosal edema and neutrophil infiltration. All of these symptoms were found to be normal in treated groups. In general, the results of the present investigation revealed the gastroprotective activity of the extract through antioxidant mechanism.
KW - Aspirin-induced ulcer
KW - Ethanol-induced ulcer
KW - Punica granatum
KW - Ulcer
UR - http://www.scopus.com/inward/record.url?scp=9644291471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9644291471&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2004.09.007
DO - 10.1016/j.jep.2004.09.007
M3 - Article
C2 - 15588667
AN - SCOPUS:9644291471
SN - 0378-8741
VL - 96
SP - 171
EP - 176
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 1-2
ER -