TY - JOUR
T1 - The inherited genetics of ovarian and endometrial cancer
AU - Gayther, Simon A.
AU - Pharoah, Paul D.P.
PY - 2010/6
Y1 - 2010/6
N2 - Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in women in developed countries, after breast, lung, and colorectal cancer. In the United States alone, in 2008 there were about 40. 000 new diagnoses of endometrial cancer and 7500 disease-related deaths. For ovarian cancer, there were about 22. 000 new diagnoses and 15. 000 deaths over the same period. The purpose of this article is to review the recent developments in the inherited genetics of ovarian and endometrial cancer, with particular attention to recent progress in identifying common low-penetrance susceptibility genes and their clinical implications.
AB - Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in women in developed countries, after breast, lung, and colorectal cancer. In the United States alone, in 2008 there were about 40. 000 new diagnoses of endometrial cancer and 7500 disease-related deaths. For ovarian cancer, there were about 22. 000 new diagnoses and 15. 000 deaths over the same period. The purpose of this article is to review the recent developments in the inherited genetics of ovarian and endometrial cancer, with particular attention to recent progress in identifying common low-penetrance susceptibility genes and their clinical implications.
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U2 - 10.1016/j.gde.2010.03.001
DO - 10.1016/j.gde.2010.03.001
M3 - Review article
C2 - 20456938
AN - SCOPUS:77953615401
SN - 0959-437X
VL - 20
SP - 231
EP - 238
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 3
ER -