Abstract
CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity.
Original language | English (US) |
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Article number | e1188226 |
Journal | Molecular and Cellular Oncology |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Jul 3 2016 |
Externally published | Yes |
Keywords
- CENP-A
- CUL4A-RBX1-COPS8 E3 ligase
- centromere
- centromere identity
- dimerization
- epigenetics
- kinetochore
- lysine 124 (K124)
- monoubiquitin-fused CENP-A mutant
- neocentromere
- ubiquitylation
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research