The inheritance of centromere identity

Yohei Niikura, Risa Kitagawa, Katsumi Kitagawa

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity.

Original languageEnglish (US)
Article numbere1188226
JournalMolecular and Cellular Oncology
Volume3
Issue number4
DOIs
StatePublished - Jul 3 2016
Externally publishedYes

Keywords

  • CENP-A
  • centromere
  • centromere identity
  • CUL4A-RBX1-COPS8 E3 ligase
  • dimerization
  • epigenetics
  • kinetochore
  • lysine 124 (K124)
  • monoubiquitin-fused CENP-A mutant
  • neocentromere
  • ubiquitylation

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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