A series of in vitro experiments using pregnenolone 14C 4 and progesterone 14C 4 as precursors were performed to determine the effects of prolonged ACTH administration on adrenal steroid biogenesis in the rat. Under ACTH administration there was a tendency for the isolated steroids to have larger quantities and specific activities from both precursors than under control conditions. In contrast to the rabbit, the rat did not produce any detectable amounts of 17 α hydroxylated steroids under either control or prolonged ACTH treatment using the very sensitive double isotope derivative assay for quantitation.
|Original language||English (US)|
|Number of pages||12|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - Dec 1 1976|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)