The Influence of Long-term Aloe vera Ingestion on Age-related Disease in Male Fischer 344 Rats

Yuji Ikeno, Gene B. Hubbard, Shuko Lee, Byung Pal Yu, Jeremiah T. Herlihy

Research output: Contribution to journalArticle

25 Scopus citations


The effects of long-term Aloe vcra ingestion on age-related diseases were investigated using male specific pathogen-free (SPF) Fischer 344 rats. Experimental animals were divided into four groups: Group A, the control rats fed a semi-synthetic diet without Aloe vera; Group B, rats fed a diet containing 1% freeze-dried Aloe vcra filet; Group C, rats fed a diet containing 1% charcoal-processed, freeze-dried Aloe vera filet; and Group D, rats fed the control diet and given whole leaf charcoal-processed Aloe vera (0.02%) in the drinking water. This study demonstrates that life-long Aloe vera ingestion produced neither harmful effects nor deleterious changes. In addition, Aloe vera ingestion appeared to be associated with some beneficial effects on age-related diseases. Groups B exhibited significantly less occurrence of multiple causes of death, and a slightly lower incidence of fatal chronic nephropathy compared with Group A rats. Groups B and C rats showed the trend, slightly lower incidences of thrombosis in the cardiac atrium than Group A rats. Therefore, these findings suggest that life-long Aloe vera ingestion does not cause any obvious harmful and deleterious side effects, and could also be beneficial for the prevention of age-related pathology.

Original languageEnglish (US)
Pages (from-to)712-718
Number of pages7
JournalPhytotherapy Research
Issue number8
StatePublished - Dec 1 2002



  • Age-related disease
  • Aging
  • Aloe vera
  • Longevity
  • Rat

ASJC Scopus subject areas

  • Pharmacology

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