The Influence of Long-term Aloe vera Ingestion on Age-related Disease in Male Fischer 344 Rats

Yuji Ikeno, Gene B. Hubbard, Shuko Lee, Byung Pal Yu, Jeremiah T. Herlihy

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of long-term Aloe vcra ingestion on age-related diseases were investigated using male specific pathogen-free (SPF) Fischer 344 rats. Experimental animals were divided into four groups: Group A, the control rats fed a semi-synthetic diet without Aloe vera; Group B, rats fed a diet containing 1% freeze-dried Aloe vcra filet; Group C, rats fed a diet containing 1% charcoal-processed, freeze-dried Aloe vera filet; and Group D, rats fed the control diet and given whole leaf charcoal-processed Aloe vera (0.02%) in the drinking water. This study demonstrates that life-long Aloe vera ingestion produced neither harmful effects nor deleterious changes. In addition, Aloe vera ingestion appeared to be associated with some beneficial effects on age-related diseases. Groups B exhibited significantly less occurrence of multiple causes of death, and a slightly lower incidence of fatal chronic nephropathy compared with Group A rats. Groups B and C rats showed the trend, slightly lower incidences of thrombosis in the cardiac atrium than Group A rats. Therefore, these findings suggest that life-long Aloe vera ingestion does not cause any obvious harmful and deleterious side effects, and could also be beneficial for the prevention of age-related pathology.

Original languageEnglish (US)
Pages (from-to)712-718
Number of pages7
JournalPhytotherapy Research
Volume16
Issue number8
DOIs
StatePublished - 2002

Fingerprint

Aloe
Inbred F344 Rats
Rats
Eating
Nutrition
Charcoal
Diet
Rat control
Specific Pathogen-Free Organisms
Formulated Food
Pathology
Pathogens
Incidence
Drinking Water
Animals
Cause of Death
Thrombosis
Control Groups

Keywords

  • Age-related disease
  • Aging
  • Aloe vera
  • Longevity
  • Rat

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

The Influence of Long-term Aloe vera Ingestion on Age-related Disease in Male Fischer 344 Rats. / Ikeno, Yuji; Hubbard, Gene B.; Lee, Shuko; Yu, Byung Pal; Herlihy, Jeremiah T.

In: Phytotherapy Research, Vol. 16, No. 8, 2002, p. 712-718.

Research output: Contribution to journalArticle

Ikeno, Yuji ; Hubbard, Gene B. ; Lee, Shuko ; Yu, Byung Pal ; Herlihy, Jeremiah T. / The Influence of Long-term Aloe vera Ingestion on Age-related Disease in Male Fischer 344 Rats. In: Phytotherapy Research. 2002 ; Vol. 16, No. 8. pp. 712-718.
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