The influence of dietary protein source on longevity and age-related disease processes of Fischer rats

K. Iwasaki; C. A. Gleiser; E. J. Masoro; C. A. McMahan; E. Seo; B. P. Yu

doi:10.1093/geronj/43.1.B5

The influence of dietary protein source on longevity and age-related disease processes of Fischer rats

K. Iwasaki, C. A. Gleiser, E. J. Masoro, C. A. McMahan, E. Seo, B. P. Yu

Pathology

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

Abstract

The influence of replacing dietary casein with soy protein on longevity and age-related pathologic lesions of male Fischer 344 rats was investigated. Caloric intake and body weights were similar for rats on the two diets. Rats on the soy protein-containing diet had a median length of life of 844 days compared to 730 days for those on the casein-containing diet (p<.002), and the ages of the 10th percentile survivors were 937 and 857 days, respectively (p<.02). The progression of chronic nephropathy was markedly retarded by replacing casein with soy protein. Only 7% of the rats dying spontaneously on the soy protein-containing diet exhibited end-stage chronic nephropathy compared to 41% of the rats on the casein-containing diet. Clearly, the soy protein-containing diet enables ad libitum fed male Fischer 344 rats to be used as a model for aging research without the occurrence of renal failure as a major confounding problem.

Original language	English (US)
Pages (from-to)	B5-B12
Journal	Journals of Gerontology
Volume	43
Issue number	1
DOIs	https://doi.org/10.1093/geronj/43.1.B5
State	Published - Jan 1 1988

ASJC Scopus subject areas

Aging

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title = "The influence of dietary protein source on longevity and age-related disease processes of Fischer rats",

abstract = "The influence of replacing dietary casein with soy protein on longevity and age-related pathologic lesions of male Fischer 344 rats was investigated. Caloric intake and body weights were similar for rats on the two diets. Rats on the soy protein-containing diet had a median length of life of 844 days compared to 730 days for those on the casein-containing diet (p<.002), and the ages of the 10th percentile survivors were 937 and 857 days, respectively (p<.02). The progression of chronic nephropathy was markedly retarded by replacing casein with soy protein. Only 7% of the rats dying spontaneously on the soy protein-containing diet exhibited end-stage chronic nephropathy compared to 41% of the rats on the casein-containing diet. Clearly, the soy protein-containing diet enables ad libitum fed male Fischer 344 rats to be used as a model for aging research without the occurrence of renal failure as a major confounding problem.",

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AU - Gleiser, C. A.

AU - Masoro, E. J.

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AU - Seo, E.

AU - Yu, B. P.

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N2 - The influence of replacing dietary casein with soy protein on longevity and age-related pathologic lesions of male Fischer 344 rats was investigated. Caloric intake and body weights were similar for rats on the two diets. Rats on the soy protein-containing diet had a median length of life of 844 days compared to 730 days for those on the casein-containing diet (p<.002), and the ages of the 10th percentile survivors were 937 and 857 days, respectively (p<.02). The progression of chronic nephropathy was markedly retarded by replacing casein with soy protein. Only 7% of the rats dying spontaneously on the soy protein-containing diet exhibited end-stage chronic nephropathy compared to 41% of the rats on the casein-containing diet. Clearly, the soy protein-containing diet enables ad libitum fed male Fischer 344 rats to be used as a model for aging research without the occurrence of renal failure as a major confounding problem.

AB - The influence of replacing dietary casein with soy protein on longevity and age-related pathologic lesions of male Fischer 344 rats was investigated. Caloric intake and body weights were similar for rats on the two diets. Rats on the soy protein-containing diet had a median length of life of 844 days compared to 730 days for those on the casein-containing diet (p<.002), and the ages of the 10th percentile survivors were 937 and 857 days, respectively (p<.02). The progression of chronic nephropathy was markedly retarded by replacing casein with soy protein. Only 7% of the rats dying spontaneously on the soy protein-containing diet exhibited end-stage chronic nephropathy compared to 41% of the rats on the casein-containing diet. Clearly, the soy protein-containing diet enables ad libitum fed male Fischer 344 rats to be used as a model for aging research without the occurrence of renal failure as a major confounding problem.

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