The influence of anesthetics on the estrogen-induced afternoon prolactin surge. Althesin does not block the surge

William P. Clarke; Richard R. Gala

doi:10.1016/0024-3205(81)90244-7

The influence of anesthetics on the estrogen-induced afternoon prolactin surge. Althesin does not block the surge

William P. Clarke, Richard R. Gala

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effect of continuous anesthesia produced by ether, ketamine, urethane and althesin on the afternoon prolactin (PRL) surge was examined using aortic catheters in ovariectomized, estrogentreated rats. Ether and ketamine (ip or ia) completely abolished the diurnal PRL surge. Urethane (ip) from two sources and administered at two doses, which produced surgical anesthesia, initially suppressed the PRL surge, however, PRL levels rose slightly in the early evening. The effect of althesin (ip) on the afternoon PRL surge was variable; in some animals the surge was similar to that seen in unanesthetized controls, while in others the surge was reduced or absent. The variable effect of althesin (ip) seemed to be a result of fluctuations in the depth of anesthesia since ia infusion of althesin at a constant rate did not suppress the afternoon PRL surge.

Original language	English (US)
Pages (from-to)	277-284
Number of pages	8
Journal	Life Sciences
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/0024-3205(81)90244-7
State	Published - Jul 20 1981
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(81)90244-7

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title = "The influence of anesthetics on the estrogen-induced afternoon prolactin surge. Althesin does not block the surge",

abstract = "The effect of continuous anesthesia produced by ether, ketamine, urethane and althesin on the afternoon prolactin (PRL) surge was examined using aortic catheters in ovariectomized, estrogentreated rats. Ether and ketamine (ip or ia) completely abolished the diurnal PRL surge. Urethane (ip) from two sources and administered at two doses, which produced surgical anesthesia, initially suppressed the PRL surge, however, PRL levels rose slightly in the early evening. The effect of althesin (ip) on the afternoon PRL surge was variable; in some animals the surge was similar to that seen in unanesthetized controls, while in others the surge was reduced or absent. The variable effect of althesin (ip) seemed to be a result of fluctuations in the depth of anesthesia since ia infusion of althesin at a constant rate did not suppress the afternoon PRL surge.",

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T1 - The influence of anesthetics on the estrogen-induced afternoon prolactin surge. Althesin does not block the surge

AU - Clarke, William P.

AU - Gala, Richard R.

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PY - 1981/7/20

Y1 - 1981/7/20

N2 - The effect of continuous anesthesia produced by ether, ketamine, urethane and althesin on the afternoon prolactin (PRL) surge was examined using aortic catheters in ovariectomized, estrogentreated rats. Ether and ketamine (ip or ia) completely abolished the diurnal PRL surge. Urethane (ip) from two sources and administered at two doses, which produced surgical anesthesia, initially suppressed the PRL surge, however, PRL levels rose slightly in the early evening. The effect of althesin (ip) on the afternoon PRL surge was variable; in some animals the surge was similar to that seen in unanesthetized controls, while in others the surge was reduced or absent. The variable effect of althesin (ip) seemed to be a result of fluctuations in the depth of anesthesia since ia infusion of althesin at a constant rate did not suppress the afternoon PRL surge.

AB - The effect of continuous anesthesia produced by ether, ketamine, urethane and althesin on the afternoon prolactin (PRL) surge was examined using aortic catheters in ovariectomized, estrogentreated rats. Ether and ketamine (ip or ia) completely abolished the diurnal PRL surge. Urethane (ip) from two sources and administered at two doses, which produced surgical anesthesia, initially suppressed the PRL surge, however, PRL levels rose slightly in the early evening. The effect of althesin (ip) on the afternoon PRL surge was variable; in some animals the surge was similar to that seen in unanesthetized controls, while in others the surge was reduced or absent. The variable effect of althesin (ip) seemed to be a result of fluctuations in the depth of anesthesia since ia infusion of althesin at a constant rate did not suppress the afternoon PRL surge.

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The influence of anesthetics on the estrogen-induced afternoon prolactin surge. Althesin does not block the surge

Abstract

ASJC Scopus subject areas

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