The influence of age on the renal response to water deprivation in man

J. W. Rowe; N. W. Shock; R. A. DeFronzo

doi:10.1159/000180731

The influence of age on the renal response to water deprivation in man

J. W. Rowe, N. W. Shock, R. A. DeFronzo

Research output: Contribution to journal › Article › peer-review

230 Scopus citations

Abstract

Alterations in urine concentrating ability with age were examined in 98 active community dwelling volunteers (aged 20-79 yr) who were free from evidence of diseases known to adversely affect renal function. There was a significant decrease in urine osmolality reached after 12 hr dehydration with advancing age, which could not be correlated with the age related decline in creatinine clearance. A significant age related diminution in the ability to conserve solute was also observed. This inability to conserve solute may result in diminished medullary tonicity and impaired urinary concentrating ability.

Original language	English (US)
Pages (from-to)	270-278
Number of pages	9
Journal	Nephron
Volume	17
Issue number	4
DOIs	https://doi.org/10.1159/000180731
State	Published - Jan 1 1976
Externally published	Yes

ASJC Scopus subject areas

Physiology
Nephrology
Physiology (medical)
Urology

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