The influence of age on the renal response to water deprivation in man

J. W. Rowe, N. W. Shock, R. A. DeFronzo

Research output: Contribution to journalArticlepeer-review

230 Scopus citations

Abstract

Alterations in urine concentrating ability with age were examined in 98 active community dwelling volunteers (aged 20-79 yr) who were free from evidence of diseases known to adversely affect renal function. There was a significant decrease in urine osmolality reached after 12 hr dehydration with advancing age, which could not be correlated with the age related decline in creatinine clearance. A significant age related diminution in the ability to conserve solute was also observed. This inability to conserve solute may result in diminished medullary tonicity and impaired urinary concentrating ability.

Original languageEnglish (US)
Pages (from-to)270-278
Number of pages9
JournalNephron
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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