Abstract
Alterations in urine concentrating ability with age were examined in 98 active community dwelling volunteers (aged 20-79 yr) who were free from evidence of diseases known to adversely affect renal function. There was a significant decrease in urine osmolality reached after 12 hr dehydration with advancing age, which could not be correlated with the age related decline in creatinine clearance. A significant age related diminution in the ability to conserve solute was also observed. This inability to conserve solute may result in diminished medullary tonicity and impaired urinary concentrating ability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 270-278 |
| Number of pages | 9 |
| Journal | Nephron |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1976 |
| Externally published | Yes |
ASJC Scopus subject areas
- Physiology
- Nephrology
- Physiology (medical)
- Urology