The in vitro activation of cyclic AMP production by either forskolin or isoproterenol in the syrian hamster pineal during the day is not accompanied by an increase in melatonin production

Celsa Santana, Juan M. Guerrero, Russel J. Reiter, Maureen E. Troiani

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The role of cyclic AMP in the regulation of melatonin production was investigated in cultured Syrian hamster pineal glands. Forskolin markedly increased cyclic AMP production in pineal glands collected either late in the light period or in the dark period. The effect of forskolin was synergistically enhanced by 3-isobutylmethylxanthine, a phosphodiesterase inhibitor; however, increase in cyclic AMP after isoproterenol was only apparent in the presence of 3-isobutylmethylxanthine. Since β-adrenergic agonists are able to stimulate melatonin production late in the dark period only, these data suggest that, in the hamster pineal gland, there may be intracellular mechanisms in addition to a cyclic AMP increase required for induction of melatonin production by β-adrenergic agonists.

Original languageEnglish (US)
Pages (from-to)930-936
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume157
Issue number3
DOIs
StatePublished - Dec 30 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The in vitro activation of cyclic AMP production by either forskolin or isoproterenol in the syrian hamster pineal during the day is not accompanied by an increase in melatonin production'. Together they form a unique fingerprint.

Cite this