The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat

Joan T. Crofton; Leonard Share; Robert E. Shade; Won Jung Lee-Kwon; Maurice Manning; Wilbur H. Sawyer

doi:10.1161/01.HYP.1.1.31

The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat

Joan T. Crofton, Leonard Share, Robert E. Shade, Won Jung Lee-Kwon, Maurice Manning, Wilbur H. Sawyer

Research output: Contribution to journal › Article

232 Scopus citations

Abstract

Experiments were performed to determine the role of vasopressin in deoxycorticosterone (DOC)-salt hypertension. In order to determine if vasopressin is necessary for the development of DOC-salt hypertension, rats with hereditary diabetes insipidus (DI) and normal Long-Evans rats (LE) were unilaterally nephrectomized, treated with DOC Pivalate (30 mg/kg, week) and given saline to drink for 8 weeks. A second group of DI rats were unilaterally nephrectomized, but received no treatment. Systolic blood pressure (SBP) increased 40 mm Hg in the LE group (p < 0.01) but failed to increase significantly in either DI group. Urinary excretion of vasopressin (UADH V) and SBP were measured in unilaterally nephrectomized LE rats treated with DOC and salt (DOC-LE), salt alone (NaCI-LE) and untreated rats (H₂O-LE). The U_ADHV was elevated in DOC-LE (p < 0.01) and NaCI-LE (p < 0.05) rats, but only the DOC-LE rats became hypertensive. Finally, the I.V. injection of analogs of vasopressin, which block its pressor but not antidluretic activity, lowered mean arterial blood pressure 27 ± 5 mm Hg in 11 conscious DOC-salt hypertensive rats. It is concluded that vasopressin plays a major role as a pressor agent in both the onset and maintenance of DOC-salt hypertension.

Original language	English (US)
Pages (from-to)	31-38
Number of pages	8
Journal	Hypertension
Volume	1
Issue number	1
DOIs	https://doi.org/10.1161/01.HYP.1.1.31
State	Published - Jan 1979

Keywords

Antidiuretic hormone Brattleboro rat
Diabetes insipidus
Doc-salt hypertension
Vasopressin
Vasopressin competitive inhibitor

ASJC Scopus subject areas

Internal Medicine

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Crofton, J. T., Share, L., Shade, R. E., Lee-Kwon, W. J., Manning, M., & Sawyer, W. H. (1979). The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat. Hypertension, 1(1), 31-38. https://doi.org/10.1161/01.HYP.1.1.31

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title = "The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat",

abstract = "Experiments were performed to determine the role of vasopressin in deoxycorticosterone (DOC)-salt hypertension. In order to determine if vasopressin is necessary for the development of DOC-salt hypertension, rats with hereditary diabetes insipidus (DI) and normal Long-Evans rats (LE) were unilaterally nephrectomized, treated with DOC Pivalate (30 mg/kg, week) and given saline to drink for 8 weeks. A second group of DI rats were unilaterally nephrectomized, but received no treatment. Systolic blood pressure (SBP) increased 40 mm Hg in the LE group (p < 0.01) but failed to increase significantly in either DI group. Urinary excretion of vasopressin (UADH V) and SBP were measured in unilaterally nephrectomized LE rats treated with DOC and salt (DOC-LE), salt alone (NaCI-LE) and untreated rats (H2O-LE). The UADHV was elevated in DOC-LE (p < 0.01) and NaCI-LE (p < 0.05) rats, but only the DOC-LE rats became hypertensive. Finally, the I.V. injection of analogs of vasopressin, which block its pressor but not antidluretic activity, lowered mean arterial blood pressure 27 ± 5 mm Hg in 11 conscious DOC-salt hypertensive rats. It is concluded that vasopressin plays a major role as a pressor agent in both the onset and maintenance of DOC-salt hypertension.",

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AB - Experiments were performed to determine the role of vasopressin in deoxycorticosterone (DOC)-salt hypertension. In order to determine if vasopressin is necessary for the development of DOC-salt hypertension, rats with hereditary diabetes insipidus (DI) and normal Long-Evans rats (LE) were unilaterally nephrectomized, treated with DOC Pivalate (30 mg/kg, week) and given saline to drink for 8 weeks. A second group of DI rats were unilaterally nephrectomized, but received no treatment. Systolic blood pressure (SBP) increased 40 mm Hg in the LE group (p < 0.01) but failed to increase significantly in either DI group. Urinary excretion of vasopressin (UADH V) and SBP were measured in unilaterally nephrectomized LE rats treated with DOC and salt (DOC-LE), salt alone (NaCI-LE) and untreated rats (H2O-LE). The UADHV was elevated in DOC-LE (p < 0.01) and NaCI-LE (p < 0.05) rats, but only the DOC-LE rats became hypertensive. Finally, the I.V. injection of analogs of vasopressin, which block its pressor but not antidluretic activity, lowered mean arterial blood pressure 27 ± 5 mm Hg in 11 conscious DOC-salt hypertensive rats. It is concluded that vasopressin plays a major role as a pressor agent in both the onset and maintenance of DOC-salt hypertension.

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