The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat

Joan T. Crofton, Leonard Share, Robert E. Shade, Won Jung Lee-Kwon, Maurice Manning, Wilbur H. Sawyer

    Research output: Contribution to journalArticlepeer-review

    232 Scopus citations


    Experiments were performed to determine the role of vasopressin in deoxycorticosterone (DOC)-salt hypertension. In order to determine if vasopressin is necessary for the development of DOC-salt hypertension, rats with hereditary diabetes insipidus (DI) and normal Long-Evans rats (LE) were unilaterally nephrectomized, treated with DOC Pivalate (30 mg/kg, week) and given saline to drink for 8 weeks. A second group of DI rats were unilaterally nephrectomized, but received no treatment. Systolic blood pressure (SBP) increased 40 mm Hg in the LE group (p < 0.01) but failed to increase significantly in either DI group. Urinary excretion of vasopressin (UADH V) and SBP were measured in unilaterally nephrectomized LE rats treated with DOC and salt (DOC-LE), salt alone (NaCI-LE) and untreated rats (H2O-LE). The UADHV was elevated in DOC-LE (p < 0.01) and NaCI-LE (p < 0.05) rats, but only the DOC-LE rats became hypertensive. Finally, the I.V. injection of analogs of vasopressin, which block its pressor but not antidluretic activity, lowered mean arterial blood pressure 27 ± 5 mm Hg in 11 conscious DOC-salt hypertensive rats. It is concluded that vasopressin plays a major role as a pressor agent in both the onset and maintenance of DOC-salt hypertension.

    Original languageEnglish (US)
    Pages (from-to)31-38
    Number of pages8
    Issue number1
    StatePublished - Jan 1979


    • Antidiuretic hormone Brattleboro rat
    • Diabetes insipidus
    • Doc-salt hypertension
    • Vasopressin
    • Vasopressin competitive inhibitor

    ASJC Scopus subject areas

    • Internal Medicine


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