The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections

Jordi B. Torrelles; Blanca I. Restrepo; Yidong Bai; Corinna Ross; Larry S. Schlesinger; Joanne Turner

doi:10.3389/fragi.2022.818700

The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections

Jordi B. Torrelles, Blanca I. Restrepo, Yidong Bai, Corinna Ross, Larry S. Schlesinger, Joanne Turner

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.

Original language	English (US)
Article number	818700
Journal	Frontiers in Aging
Volume	3
DOIs	https://doi.org/10.3389/fragi.2022.818700
State	Published - 2022

Keywords

aging
lung environment
oxidative stress
respiratory infections
tuberculosis

ASJC Scopus subject areas

Aging
Genetics
Molecular Biology
Physiology

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10.3389/fragi.2022.818700

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title = "The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections",

abstract = "Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.",

keywords = "aging, lung environment, oxidative stress, respiratory infections, tuberculosis",

author = "Torrelles, {Jordi B.} and Restrepo, {Blanca I.} and Yidong Bai and Corinna Ross and Schlesinger, {Larry S.} and Joanne Turner",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Torrelles, Restrepo, Bai, Ross, Schlesinger and Turner.",

year = "2022",

doi = "10.3389/fragi.2022.818700",

language = "English (US)",

volume = "3",

journal = "Frontiers in Aging",

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T1 - The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections

AU - Torrelles, Jordi B.

AU - Restrepo, Blanca I.

AU - Bai, Yidong

AU - Ross, Corinna

AU - Schlesinger, Larry S.

AU - Turner, Joanne

PY - 2022

Y1 - 2022

N2 - Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.

AB - Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.

KW - aging

KW - lung environment

KW - oxidative stress

KW - respiratory infections

KW - tuberculosis

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M3 - Short survey

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AN - SCOPUS:85140649213

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VL - 3

JO - Frontiers in Aging

JF - Frontiers in Aging

M1 - 818700

ER -

The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections

Abstract

Keywords

ASJC Scopus subject areas

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