The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections

Jordi B. Torrelles, Blanca I. Restrepo, Yidong Bai, Corinna Ross, Larry S. Schlesinger, Joanne Turner

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations

Abstract

Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.

Original languageEnglish (US)
Article number818700
JournalFrontiers in Aging
Volume3
DOIs
StatePublished - 2022

Keywords

  • aging
  • lung environment
  • oxidative stress
  • respiratory infections
  • tuberculosis

ASJC Scopus subject areas

  • Genetics
  • Aging
  • Molecular Biology
  • Physiology

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