The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease

Brent R. Weil; Mariuxi C. Manukyan; Jeremy L. Herrmann; Aaron M. Abarbanell; Jeffrey A. Poynter; Yue Wang; Daniel R. Meldrum

doi:10.1016/j.jss.2010.07.019

The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease

Brent R. Weil, Mariuxi C. Manukyan, Jeremy L. Herrmann, Aaron M. Abarbanell, Jeffrey A. Poynter, Yue Wang, Daniel R. Meldrum

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.

Original language	English (US)
Pages (from-to)	78-86
Number of pages	9
Journal	Journal of Surgical Research
Volume	167
Issue number	1
DOIs	https://doi.org/10.1016/j.jss.2010.07.019
State	Published - May 1 2011
Externally published	Yes

Keywords

Crohn's disease
SIRS
cancer
immunomodulation
immunoprivilege
inflammation
sepsis
transplant
tumor

ASJC Scopus subject areas

Surgery

Access to Document

10.1016/j.jss.2010.07.019

Cite this

@article{a41909a29f0c4c53aacf1ac25e9ac0e7,

title = "The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease",

abstract = "Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.",

keywords = "Crohn's disease, SIRS, cancer, immunomodulation, immunoprivilege, inflammation, sepsis, transplant, tumor",

author = "Weil, {Brent R.} and Manukyan, {Mariuxi C.} and Herrmann, {Jeremy L.} and Abarbanell, {Aaron M.} and Poynter, {Jeffrey A.} and Yue Wang and Meldrum, {Daniel R.}",

year = "2011",

month = may,

day = "1",

doi = "10.1016/j.jss.2010.07.019",

language = "English (US)",

volume = "167",

pages = "78--86",

journal = "Journal of Surgical Research",

issn = "0022-4804",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - The immunomodulatory properties of mesenchymal stem cells

T2 - Implications for surgical disease

AU - Weil, Brent R.

AU - Manukyan, Mariuxi C.

AU - Herrmann, Jeremy L.

AU - Abarbanell, Aaron M.

AU - Poynter, Jeffrey A.

AU - Wang, Yue

AU - Meldrum, Daniel R.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.

AB - Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.

KW - Crohn's disease

KW - SIRS

KW - cancer

KW - immunomodulation

KW - immunoprivilege

KW - inflammation

KW - sepsis

KW - transplant

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=79953033149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953033149&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2010.07.019

DO - 10.1016/j.jss.2010.07.019

M3 - Review article

C2 - 20869073

AN - SCOPUS:79953033149

SN - 0022-4804

VL - 167

SP - 78

EP - 86

JO - Journal of Surgical Research

JF - Journal of Surgical Research

IS - 1

ER -

The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this