The immunology of bipolar disorder

Izabela Guimarães Barbosa, Rodrigo Machado-Vieira, Jair C. Soares, Antonio L. Teixeira

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


Bipolar disorder (BD) is a psychiatric condition associated with elevated frequency of clinical comorbidities and cognitive impairment. The neurobiology of BD is not completely understood. Recent evidence has implicated immune dysfunction in its physiopathology. Here, we review several data supporting the presence of immunological dysfunction in BD: (i) increased frequency of autoimmune diseases; (ii) distinct immune cell profile; (iii) release of/altered cytokines by stimulated mononuclear cells; (iv) elevated levels of circulating immune markers, and (v) inflammatory changes in the central nervous system. We also discuss the interplay between immunological dysfunction and neuroprogression in BD.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
Issue number2-3
StatePublished - 2014
Externally publishedYes


  • Aspirin
  • Depression
  • Interleukin
  • Lymphocytes
  • Mania
  • Mood disorder

ASJC Scopus subject areas

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems


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