The hypophyseal-adrenal axis in the protein-calorie malnourished rat

D. C. Herbert, A. J. Carrillo

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Male rats were fed an 8% low protein diet for 30 consecutive days beginning at 20 days of age. On day 50, the effect of the diet was evaluated on the hypophyseal-adrenal axis and the observations compared with those noted in age-matched controls fed a standard laboratory diet. The malnourished animals had significantly larger adrenal gland weights, relative to body size, and higher levels of serum corticosterone. Additionally, the number of ACTH-secreting cells in the pituitary glands of these rats was 63.8% greater than that present in the controls. These results suggest that ACTH secretion and adrenocortical physiology are stimulated under conditions of experimentally induced protein-calorie malnutrition.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalHormone and Metabolic Research
Issue number4
StatePublished - 1982

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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