The human transferrin gene: 5′ region contains conserved sequences which match the control elements regulated by heavy metals, glucocorticoids and acute phase reaction

Gwendolyn S. Adrian, Barry W. Korinek, Barbara H. Bowman, Yang Funmei

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Transferrin is a major plasma protein that transports iron to proliferating cells throughout the body. A clone containing the 5' region of the human transferrin gene has been isolated and characterized. A 14 kb EcoRI fragment was identified that contained the first 8 exons of the transferrin gene and 3.6 kb of its 5' flanking region. Conserved sequences identical or homologous to regulatory elements responding to heavy metals, glucocorticoid receptor and a putative acute phase reaction signal were identified in the 5' flanking region and intron 1. Also, the regulatory region of the transferrin gene contains a 14-bp sequence which closely matches sequences found in the interleukin-2 and γ-interferon genes. All three genes are expressed by T lymphocytes before proliferation. A secondary loop structure similar to that proposed for the ovotransferrin gene can be formed by sequences in the 5' untranslated region of the transferrin mRNA.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalGene
Volume49
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • Plasma proteins
  • T lymphocytes
  • cis-regulatory regions
  • cloning vector
  • exon
  • inter-leukin
  • interferon
  • intron
  • metallothionein
  • promoter
  • recombinant DNA

ASJC Scopus subject areas

  • Genetics

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