The human apolipoprotein A-II gene is located on chromosome 1

K. J. Lackner; S. W. Law; H. B. Brewer; A. Y. Sakaguchi; S. L. Naylor

doi:10.1016/0006-291X(84)91172-0

The human apolipoprotein A-II gene is located on chromosome 1

K. J. Lackner, S. W. Law, H. B. Brewer, A. Y. Sakaguchi, S. L. Naylor

Research output: Contribution to journal › Article

28 Scopus citations

Abstract

Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.

Original language	English (US)
Pages (from-to)	877-883
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	122
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(84)91172-0
State	Published - Aug 16 1984
Externally published	Yes

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ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Cite this

Lackner, K. J., Law, S. W., Brewer, H. B., Sakaguchi, A. Y., & Naylor, S. L. (1984). The human apolipoprotein A-II gene is located on chromosome 1. Biochemical and Biophysical Research Communications, 122(3), 877-883. https://doi.org/10.1016/0006-291X(84)91172-0

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abstract = "Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.",

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AU - Lackner, K. J.

AU - Law, S. W.

AU - Brewer, H. B.

AU - Sakaguchi, A. Y.

AU - Naylor, S. L.

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AB - Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.

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10.1016/0006-291X(84)91172-0