Abstract
Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 877-883 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 122 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 16 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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The human apolipoprotein A-II gene is located on chromosome 1. / Lackner, K. J.; Law, S. W.; Brewer, H. B.; Sakaguchi, Alan Y; Naylor, S. L.
In: Biochemical and Biophysical Research Communications, Vol. 122, No. 3, 16.08.1984, p. 877-883.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The human apolipoprotein A-II gene is located on chromosome 1
AU - Lackner, K. J.
AU - Law, S. W.
AU - Brewer, H. B.
AU - Sakaguchi, Alan Y
AU - Naylor, S. L.
PY - 1984/8/16
Y1 - 1984/8/16
N2 - Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.
AB - Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.
UR - http://www.scopus.com/inward/record.url?scp=0021231066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021231066&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(84)91172-0
DO - 10.1016/0006-291X(84)91172-0
M3 - Article
C2 - 6433912
AN - SCOPUS:0021231066
VL - 122
SP - 877
EP - 883
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -