The human apolipoprotein A-II gene is located on chromosome 1

K. J. Lackner; S. W. Law; H. B. Brewer; A. Y. Sakaguchi; S. L. Naylor

doi:10.1016/0006-291X(84)91172-0

The human apolipoprotein A-II gene is located on chromosome 1

K. J. Lackner, S. W. Law, H. B. Brewer, A. Y. Sakaguchi, S. L. Naylor

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.

Original language	English (US)
Pages (from-to)	877-883
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	122
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(84)91172-0
State	Published - Aug 16 1984
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "The human apolipoprotein A-II gene is located on chromosome 1",

abstract = "Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.",

author = "Lackner, {K. J.} and Law, {S. W.} and Brewer, {H. B.} and Sakaguchi, {A. Y.} and Naylor, {S. L.}",

year = "1984",

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doi = "10.1016/0006-291X(84)91172-0",

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T1 - The human apolipoprotein A-II gene is located on chromosome 1

AU - Lackner, K. J.

AU - Law, S. W.

AU - Brewer, H. B.

AU - Sakaguchi, A. Y.

AU - Naylor, S. L.

PY - 1984/8/16

Y1 - 1984/8/16

N2 - Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.

AB - Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.

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