The human apolipoprotein A-II gene is located on chromosome 1

K. J. Lackner, S. W. Law, H. B. Brewer, A. Y. Sakaguchi, S. L. Naylor

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21 → qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosome 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.

Original languageEnglish (US)
Pages (from-to)877-883
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume122
Issue number3
DOIs
StatePublished - Aug 16 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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