The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors

Fernando E. Membreno; Eric J. Lawitz

doi:10.1016/j.cld.2011.05.003

The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors

Fernando E. Membreno, Eric J. Lawitz

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical trials. Direct-acting antiviral combination trials that have already shown some early promising results even in the setting of interferon-sparing antiviral regimens are discussed.

Original language	English (US)
Pages (from-to)	611-626
Number of pages	16
Journal	Clinics in Liver Disease
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.cld.2011.05.003
State	Published - Aug 2011
Externally published	Yes

Keywords

Hepatitis C virus
NS5B nucleoside inhibitors
Non-nucleoside inhibitors
Polymerase inhibitors

ASJC Scopus subject areas

Hepatology

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10.1016/j.cld.2011.05.003

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AB - This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical trials. Direct-acting antiviral combination trials that have already shown some early promising results even in the setting of interferon-sparing antiviral regimens are discussed.

KW - Hepatitis C virus

KW - NS5B nucleoside inhibitors

KW - Non-nucleoside inhibitors

KW - Polymerase inhibitors

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The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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