@article{fa8a74c2d4e74646bd6eb9a957c32f06,
title = "The guanine exchange factor gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth",
abstract = "The generation of neuronal morphology requires transport vesicles originating from the Golgi apparatus (GA) to deliver specialized components to the axon and dendrites. Drosophila Arfaptin is a membrane-binding protein localized to the GA that is required for the growth of the presynaptic nerve terminal. Here we provide biochemical, cellular and genetic evidence that the small GTPase Arl1 and the guanine-nucleotide exchange factor (GEF) Gartenzwerg are required for Arfaptin function at the Golgi during synapse growth. Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology.",
keywords = "Arfaptin, Golgi apparatus, Small GTPase, Synapse growth",
author = "Leo Chang and Tabita Kreko-Pierce and Eaton, {Benjamin A.}",
note = "Funding Information: The authors would like to thank Yimin Wu for excellent technical support on this manuscript. An RO1 award to B.A.E. (NS062811) from the National Institute of Neurological Disorders and Stroke supported this work. The Grant T32-AG021890 from the National Institute of Aging supported L.C. This research was funded by NIH grants NS062811 to B.A.E. and T32-AG021890 to L.C. Funding Information: This research was funded by NIH grants NS062811 to B.A.E. and T32-AG021890 to L.C. Funding Information: The authors would like to thank Yimin Wu for excellent technical support on this manuscript. An RO1 award to B.A.E. (NS062811) from the National Institute of Neurological Disorders and Stroke supported this work. The Grant T32-AG021890 from the National Institute of Aging supported L.C. Publisher Copyright: {\textcopyright} 2015. Published by The Company of Biologists Ltd |.",
year = "2015",
doi = "10.1242/bio.011262",
language = "English (US)",
volume = "4",
pages = "947--953",
journal = "Biology Open",
issn = "2046-6390",
publisher = "Company of Biologists Ltd",
number = "8",
}