The guanine exchange factor gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth

Leo Chang, Tabita Kreko-Pierce, Benjamin A Eaton

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The generation of neuronal morphology requires transport vesicles originating from the Golgi apparatus (GA) to deliver specialized components to the axon and dendrites. Drosophila Arfaptin is a membrane-binding protein localized to the GA that is required for the growth of the presynaptic nerve terminal. Here we provide biochemical, cellular and genetic evidence that the small GTPase Arl1 and the guanine-nucleotide exchange factor (GEF) Gartenzwerg are required for Arfaptin function at the Golgi during synapse growth. Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology.

Original languageEnglish (US)
Pages (from-to)947-953
Number of pages7
JournalBiology Open
Volume4
Issue number8
DOIs
StatePublished - 2015

Keywords

  • Arfaptin
  • Golgi apparatus
  • Small GTPase
  • Synapse growth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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