The tumor promoter 12-0-tetmlecanoyl phorbol-13-acetate (TPA) does not stimulate the growth of human epidermal cells in foreskin explant cultures; a dosedependent inhibition is seen at doses higher than 10-5 μg/ml . TPA also inhibits epidermal growth factor-stimulated growth and does not induce ornithine decarboxylase activity or increase potyamine levels. This is not due to the rapid breakdown of TPA, since TPA is not metabolized to any appredable extent.
ASJC Scopus subject areas
- Cancer Research