The growth of cultured human foreskin keratinocytes is not stimulated by a tumor promoter

Susan M. Fischer, Aurora Viaje, Gerald D. Mills, Edith W. Wong, Charles E. Weeks, Thomas J. Slaga

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The tumor promoter 12-0-tetmlecanoyl phorbol-13-acetate (TPA) does not stimulate the growth of human epidermal cells in foreskin explant cultures; a dosedependent inhibition is seen at doses higher than 10-5 μg/ml . TPA also inhibits epidermal growth factor-stimulated growth and does not induce ornithine decarboxylase activity or increase potyamine levels. This is not due to the rapid breakdown of TPA, since TPA is not metabolized to any appredable extent.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalCarcinogenesis
Volume5
Issue number1
DOIs
StatePublished - Jan 1984
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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