The great masquerader of malignancy: Chronic intestinal pseudo-obstruction

Josephine A. Taverna, Hani M. Babiker, Seongseok Yun, Maria C. Bishop, Sarah Lau-Braunhut, Paul N. Meyer, Thomas Enzler

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Paraneoplastic syndromes can precede the initial manifestation and diagnosis of cancer. Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than the local presence of tumor cells. These phenomena are mediated by humoral factors secreted by tumor cells or by tumor mediated immune responses. Among paraneoplastic syndromes, chronic intestinal pseudo-obstruction (CIPO) is rare and represents a particularly difficult clinical challenge. Paraneoplastic CIPO is a highly morbid syndrome characterized by impaired gastrointestinal propulsion with symptoms and signs of mechanical bowel obstruction. Clinical outcomes of paraneoplastic CIPO are often deleterious. The current standard of care for the management of CIPO includes supportive treatment with promotility and anti-secretory agents. However, the majority of patients with CIPO eventually require the resection of the non-functioning gut segment. Here, we present a 62-year-old patient with anti-Hu antibody associated paraneoplastic CIPO and underlying small cell lung cancer who underwent treatment with cisplatin and etoposide. Herein, we discuss diagnosis, prognosis, proposed mechanisms, treatment options, and future potential therapeutic strategies of paraneoplastic CIPO.

Original languageEnglish (US)
Article number23
JournalBiomarker Research
Volume2
Issue number1
DOIs
StatePublished - Dec 5 2014

Keywords

  • Anti-Hu antibodies
  • Myenteric ganglioneuritis
  • Paraneoplastic chronic intestinal pseudo-obstruction
  • Small cell lung cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Biochemistry, medical

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