The geroscience hypothesis: Is it possible to change the rate of aging?

Steven N. Austad

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Aging is not a disease. It is a generalized and progressive loss of function with the passage of time that makes us increasingly vulnerable to a broad suite of diseases. The Geroscience Hypothesis asserts that any intervention that retards the aging process will simultaneously delay the onset of multiple diseases. Retarding the aging process is not only a worthwhile medical enterprise; it is achievable as shown by the fact that nature has achieved it many times. Humans, for instance, age about half as fast as their close evolutionary relatives, chimpanzees. Experimentally, dietary restriction retards aging in a variety of laboratory organisms. Dietary restriction not only increases longevity, but it also slows the rate of functional decline in many systems, delays multiple chronic diseases, and has been repeated in multiple laboratories in multiple genotypes. In addition, direct manipulation of dozens to hundreds of individual genes also appears to slow aging, as indicated by a life-lengthening effect. The knowledge gained in genetic studies has now been employed to design pharmacological interventions. The National Institute on Aging’s Interventions Testing Program has been phenomenally successful at discovering compounds that extend life in genetically heterogeneous mice. Five compounds that extend life in at least one mouse sex have been reported to date, suggesting the real possibility that successful interventions in the aging process can be developed for humans.

Original languageEnglish (US)
Title of host publicationAdvances in Geroscience
PublisherSpringer International Publishing
Pages1-36
Number of pages36
ISBN (Print)9783319232461, 9783319232454
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Keywords

  • Aging
  • Aging interventions
  • Comparative biology
  • Dietary restriction
  • Geroscience
  • Models of aging

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Social Sciences(all)
  • Psychology(all)

Cite this

Austad, S. N. (2015). The geroscience hypothesis: Is it possible to change the rate of aging? In Advances in Geroscience (pp. 1-36). Springer International Publishing. https://doi.org/10.1007/978-3-319-23246-1_1