@article{fafa50896ff14acc8a255d8593c82275,
title = "The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes",
abstract = "Fusarium oxysporum is a cross-kingdom fungal pathogen that infects plants and humans. Horizontally transferred lineage-specific (LS) chromosomes were reported to determine host-specific pathogenicity among phytopathogenic F. oxysporum. However, the existence and functional importance of LS chromosomes among human pathogenic isolates are unknown. Here we report four unique LS chromosomes in a human pathogenic strain NRRL 32931, isolated from a leukemia patient. These LS chromosomes were devoid of housekeeping genes, but were significantly enriched in genes encoding metal ion transporters and cation transporters. Homologs of NRRL 32931 LS genes, including a homolog of ceruloplasmin and the genes that contribute to the expansion of the alkaline pH-responsive transcription factor PacC/Rim1p, were also present in the genome of NRRL 47514, a strain associated with Fusarium keratitis outbreak. This study provides the first evidence, to our knowledge, for genomic compartmentalization in two human pathogenic fungal genomes and suggests an important role of LS chromosomes in niche adaptation.",
author = "Yong Zhang and He Yang and David Turra and Shiguo Zhou and Ayhan, {Dilay Hazal} and DeIulio, {Gregory A.} and Li Guo and Karen Broz and Nathan Wiederhold and Coleman, {Jeffrey J.} and Donnell, {Kerry O{\textquoteright}} and Ilan Youngster and McAdam, {Alexander J.} and Sergey Savinov and Terrance Shea and Sarah Young and Qiandong Zeng and Martijn Rep and Eric Pearlman and Schwartz, {David C.} and {Di Pietro}, Antonio and Kistler, {H. Corby} and Ma, {Li Jun}",
note = "Funding Information: We thank Dr Bruce Birren and the Broad Institute manual and automated annotation teams for their support on this and many other fungal genomic projects; Dr Frederick M. Ausubel for critical review of the manuscript; and Cindy Zhang from Boston University for drawing the diagrams shown in Fig. 1. The mention of firm names or trade products does not imply that they are endorsed or recommended by the US Department of Agriculture over other firms or similar products not mentioned. The USDA is an equal opportunity provider and employer. This project was supported by the National Research Initiative Competitive Grants Program Grant numbers 2008-35604-18800 and MASR-2009-04374 from the USDA National Institute of Food and Agriculture, the National Eye Institute of the National Institutes of Health (R01EY030150) and grant BIO2016-78923-R from the Spanish Ministerio de Econom{\'i}a y Competitividad. Data were analyzed at the Massachusetts Green High Performance Computing Center (MGHPCC). L.-J.M. is also supported by an Investigator Award in Infectious Diseases and Pathogenesis by the Burroughs Wellcome Fund BWF-1014893. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s42003-020-0770-2",
language = "English (US)",
volume = "3",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Springer Nature",
number = "1",
}