The genetics of osteoporosis

Gregory R. Mundy

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


In January 1994, Nature published an original article from Australia which suggested that one gene, the vitamin D receptor gene, was responsible for the majority of the genetic component to bone mass, which is one of the major determinants of osteoporotic fracture [1]. This article attracted the attention of the world’s press, many of which reported that the osteoporosis gene had been discovered. The article was received by the bone field with skepticism by some but great interest by all. In the following 12 months, the findings have been confirmed by several groups but not by others and the overall importance of the particular results remain unclear. However, these studies and the attention they have received have stimulated all workers in this field to think anew about how genes may control bone mass.

Original languageEnglish (US)
Pages (from-to)176-179
Number of pages4
Issue number3
StatePublished - May 1995

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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