The Genetics of Inherited Breast Cancer

Simon A. Gayther; Paul D.P. Pharoah; Bruce A.J. Ponder

doi:10.1023/A:1018779830743

The Genetics of Inherited Breast Cancer

Simon A. Gayther, Paul D.P. Pharoah, Bruce A.J. Ponder

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The isolation of BRCA1 and BRCA2 has greatly increased our understanding of the genetics of inherited breast and ovarian cancer although the functions of these genes are not yet fully understood. We will discuss the current state of knowledge about the function of BRCA1 and BRCA2 and summarize the cancer risks in women carrying a BRCA1 or BRCA2 mutation. We review the evidence for gene-gene and gene-environment interaction in modifying that risk, and discuss the contribution of BRCA1 and BRCA2 and other high penetrance genes to both inherited and sporadic breast cancer.

Original language	English (US)
Pages (from-to)	365-376
Number of pages	12
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	3
Issue number	4
DOIs	https://doi.org/10.1023/A:1018779830743
State	Published - 1998
Externally published	Yes

Keywords

BRCA1
BRCA2
Genetics

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1023/A:1018779830743

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abstract = "The isolation of BRCA1 and BRCA2 has greatly increased our understanding of the genetics of inherited breast and ovarian cancer although the functions of these genes are not yet fully understood. We will discuss the current state of knowledge about the function of BRCA1 and BRCA2 and summarize the cancer risks in women carrying a BRCA1 or BRCA2 mutation. We review the evidence for gene-gene and gene-environment interaction in modifying that risk, and discuss the contribution of BRCA1 and BRCA2 and other high penetrance genes to both inherited and sporadic breast cancer.",

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AU - Pharoah, Paul D.P.

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AB - The isolation of BRCA1 and BRCA2 has greatly increased our understanding of the genetics of inherited breast and ovarian cancer although the functions of these genes are not yet fully understood. We will discuss the current state of knowledge about the function of BRCA1 and BRCA2 and summarize the cancer risks in women carrying a BRCA1 or BRCA2 mutation. We review the evidence for gene-gene and gene-environment interaction in modifying that risk, and discuss the contribution of BRCA1 and BRCA2 and other high penetrance genes to both inherited and sporadic breast cancer.

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KW - BRCA2

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The Genetics of Inherited Breast Cancer

Abstract

Keywords

ASJC Scopus subject areas

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