The Genetic contribution to solving the cocktail-party problem

Samuel R. Mathias; Emma E.M. Knowles; Josephine Mollon; Amanda L. Rodrigue; Mary K. Woolsey; Alyssa M. Hernandez; Amy S. Garrett; Peter T. Fox; Rene L. Olvera; Juan M. Peralta; Satish Kumar; Harald HH Goring; Ravi Duggirala; Joanne E Curran; John C Blangero; David C. Glahn

doi:10.1016/j.isci.2022.104997

The Genetic contribution to solving the cocktail-party problem

Samuel R. Mathias
, Emma E.M. Knowles
, Josephine Mollon
, Amanda L. Rodrigue
, Mary K. Woolsey
, Alyssa M. Hernandez
, Amy S. Garrett
, Peter T. Fox
, Rene L. Olvera
, Juan M. Peralta
, Satish Kumar
, Harald HH Goring
, Ravi Duggirala
, Joanne E Curran
, John C Blangero
, David C. Glahn

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (h² = 0.567). The genetic correlation between SRTs and hearing thresholds (HTs) was medium (ρ_G = 0.392), suggesting that the genetic factors influencing cocktail-party listening were partially distinct from those influencing sound sensitivity. Aging and socioeconomic status also strongly influenced SRTs. These findings may represent a first step toward identifying genes for “hidden hearing loss,” or hearing problems in people with normal HTs.

Original language	English (US)
Article number	104997
Journal	iScience
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/j.isci.2022.104997
State	Published - Sep 16 2022

Keywords

Genetics
Health sciences
Human Genetics

ASJC Scopus subject areas

General

Access to Document

10.1016/j.isci.2022.104997

Cite this

Mathias, S. R., Knowles, E. E. M., Mollon, J., Rodrigue, A. L., Woolsey, M. K., Hernandez, A. M., Garrett, A. S., Fox, P. T., Olvera, R. L., Peralta, J. M., Kumar, S., Goring, H. HH., Duggirala, R., Curran, J. E., Blangero, J. C., & Glahn, D. C. (2022). The Genetic contribution to solving the cocktail-party problem. iScience, 25(9), Article 104997. https://doi.org/10.1016/j.isci.2022.104997

@article{84dbefd779ce4e97bd5005dcec9987ba,

title = "The Genetic contribution to solving the cocktail-party problem",

abstract = "Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (h2 = 0.567). The genetic correlation between SRTs and hearing thresholds (HTs) was medium (ρG = 0.392), suggesting that the genetic factors influencing cocktail-party listening were partially distinct from those influencing sound sensitivity. Aging and socioeconomic status also strongly influenced SRTs. These findings may represent a first step toward identifying genes for “hidden hearing loss,” or hearing problems in people with normal HTs.",

keywords = "Genetics, Health sciences, Human Genetics",

author = "Mathias, \{Samuel R.\} and Knowles, \{Emma E.M.\} and Josephine Mollon and Rodrigue, \{Amanda L.\} and Woolsey, \{Mary K.\} and Hernandez, \{Alyssa M.\} and Garrett, \{Amy S.\} and Fox, \{Peter T.\} and Olvera, \{Rene L.\} and Peralta, \{Juan M.\} and Satish Kumar and Goring, \{Harald HH\} and Ravi Duggirala and Curran, \{Joanne E\} and Blangero, \{John C\} and Glahn, \{David C.\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = sep,

day = "16",

doi = "10.1016/j.isci.2022.104997",

language = "English (US)",

volume = "25",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier Inc.",

number = "9",

}

TY - JOUR

T1 - The Genetic contribution to solving the cocktail-party problem

AU - Mathias, Samuel R.

AU - Knowles, Emma E.M.

AU - Mollon, Josephine

AU - Rodrigue, Amanda L.

AU - Woolsey, Mary K.

AU - Hernandez, Alyssa M.

AU - Garrett, Amy S.

AU - Fox, Peter T.

AU - Olvera, Rene L.

AU - Peralta, Juan M.

AU - Kumar, Satish

AU - Goring, Harald HH

AU - Duggirala, Ravi

AU - Curran, Joanne E

AU - Blangero, John C

AU - Glahn, David C.

PY - 2022/9/16

Y1 - 2022/9/16

N2 - Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (h2 = 0.567). The genetic correlation between SRTs and hearing thresholds (HTs) was medium (ρG = 0.392), suggesting that the genetic factors influencing cocktail-party listening were partially distinct from those influencing sound sensitivity. Aging and socioeconomic status also strongly influenced SRTs. These findings may represent a first step toward identifying genes for “hidden hearing loss,” or hearing problems in people with normal HTs.

AB - Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (h2 = 0.567). The genetic correlation between SRTs and hearing thresholds (HTs) was medium (ρG = 0.392), suggesting that the genetic factors influencing cocktail-party listening were partially distinct from those influencing sound sensitivity. Aging and socioeconomic status also strongly influenced SRTs. These findings may represent a first step toward identifying genes for “hidden hearing loss,” or hearing problems in people with normal HTs.

KW - Genetics

KW - Health sciences

KW - Human Genetics

UR - https://www.scopus.com/pages/publications/85137405879

UR - https://www.scopus.com/pages/publications/85137405879#tab=citedBy

U2 - 10.1016/j.isci.2022.104997

DO - 10.1016/j.isci.2022.104997

M3 - Article

C2 - 36111257

AN - SCOPUS:85137405879

SN - 2589-0042

VL - 25

JO - iScience

JF - iScience

IS - 9

M1 - 104997

ER -

The Genetic contribution to solving the cocktail-party problem

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this