The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome

Anthony G. Comuzzie, Tohru Funahashi, Gabriele Sonnenberg, Lisa J. Martin, Howard J. Jacob, Anne E. Kwitek Black, Diana Maas, Masahiko Takahashi, Shinji Kihara, Sachiyo Tanaka, Yuji Matsuzawa, John Blangero, Daniel Cohen, Ahmed Kissebah

    Research output: Contribution to journalArticle

    269 Scopus citations

    Abstract

    Here we present the first genetic analysis of adiponectin levels, a newly identified adipocyte-derived protein. Recent work has suggested that adiponectin may play a role in mediating the effects of body weight as a risk factor for coronary artery disease. For this analysis we assayed serum levels of adiponectin in 1100 adults of predominantly northern European ancestry distributed across 170 families. Quantitative genetic analysis of adiponectin levels detected an additive genetic heritability of 46%. The maximum LOD score detected in a genome wide scan for adiponectin levels was 4.06 (P = 7.7 × 10-6), 35 cM from pter on chromosome 5. The second largest LOD score (LOD = 3.2; P = 6.2 × 10-5) was detected on chromosome 14, 29 cM from pter. The detection of a significant linkage with a quantitative trait locus on chromosome 5 provides strong evidence for a replication of a previously reported quantitative trait locus for obesity-related phenotypes. In addition, several secondary signals offer potential evidence of replications for additional previously reported obesity-related quantitative trait loci on chromosomes 2 and 10. Not only do these results identify quantitative trait loci with significant effects on a newly described, and potentially very important, adipocyte-derived protein, they also reveal the emergence of a consistent pattern of linkage results for obesity-related traits across a number of human populations.

    Original languageEnglish (US)
    Pages (from-to)4321-4325
    Number of pages5
    JournalJournal of Clinical Endocrinology and Metabolism
    Volume86
    Issue number9
    DOIs
    StatePublished - 2001

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Biochemistry
    • Endocrinology
    • Clinical Biochemistry
    • Biochemistry, medical

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  • Cite this

    Comuzzie, A. G., Funahashi, T., Sonnenberg, G., Martin, L. J., Jacob, H. J., Kwitek Black, A. E., Maas, D., Takahashi, M., Kihara, S., Tanaka, S., Matsuzawa, Y., Blangero, J., Cohen, D., & Kissebah, A. (2001). The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. Journal of Clinical Endocrinology and Metabolism, 86(9), 4321-4325. https://doi.org/10.1210/jcem.86.9.7878