TY - JOUR
T1 - The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome
AU - Comuzzie, Anthony G.
AU - Funahashi, Tohru
AU - Sonnenberg, Gabriele
AU - Martin, Lisa J.
AU - Jacob, Howard J.
AU - Kwitek Black, Anne E.
AU - Maas, Diana
AU - Takahashi, Masahiko
AU - Kihara, Shinji
AU - Tanaka, Sachiyo
AU - Matsuzawa, Yuji
AU - Blangero, John
AU - Cohen, Daniel
AU - Kissebah, Ahmed
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Here we present the first genetic analysis of adiponectin levels, a newly identified adipocyte-derived protein. Recent work has suggested that adiponectin may play a role in mediating the effects of body weight as a risk factor for coronary artery disease. For this analysis we assayed serum levels of adiponectin in 1100 adults of predominantly northern European ancestry distributed across 170 families. Quantitative genetic analysis of adiponectin levels detected an additive genetic heritability of 46%. The maximum LOD score detected in a genome wide scan for adiponectin levels was 4.06 (P = 7.7 × 10-6), 35 cM from pter on chromosome 5. The second largest LOD score (LOD = 3.2; P = 6.2 × 10-5) was detected on chromosome 14, 29 cM from pter. The detection of a significant linkage with a quantitative trait locus on chromosome 5 provides strong evidence for a replication of a previously reported quantitative trait locus for obesity-related phenotypes. In addition, several secondary signals offer potential evidence of replications for additional previously reported obesity-related quantitative trait loci on chromosomes 2 and 10. Not only do these results identify quantitative trait loci with significant effects on a newly described, and potentially very important, adipocyte-derived protein, they also reveal the emergence of a consistent pattern of linkage results for obesity-related traits across a number of human populations.
AB - Here we present the first genetic analysis of adiponectin levels, a newly identified adipocyte-derived protein. Recent work has suggested that adiponectin may play a role in mediating the effects of body weight as a risk factor for coronary artery disease. For this analysis we assayed serum levels of adiponectin in 1100 adults of predominantly northern European ancestry distributed across 170 families. Quantitative genetic analysis of adiponectin levels detected an additive genetic heritability of 46%. The maximum LOD score detected in a genome wide scan for adiponectin levels was 4.06 (P = 7.7 × 10-6), 35 cM from pter on chromosome 5. The second largest LOD score (LOD = 3.2; P = 6.2 × 10-5) was detected on chromosome 14, 29 cM from pter. The detection of a significant linkage with a quantitative trait locus on chromosome 5 provides strong evidence for a replication of a previously reported quantitative trait locus for obesity-related phenotypes. In addition, several secondary signals offer potential evidence of replications for additional previously reported obesity-related quantitative trait loci on chromosomes 2 and 10. Not only do these results identify quantitative trait loci with significant effects on a newly described, and potentially very important, adipocyte-derived protein, they also reveal the emergence of a consistent pattern of linkage results for obesity-related traits across a number of human populations.
UR - http://www.scopus.com/inward/record.url?scp=17944362243&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17944362243&partnerID=8YFLogxK
U2 - 10.1210/jcem.86.9.7878
DO - 10.1210/jcem.86.9.7878
M3 - Article
C2 - 11549668
AN - SCOPUS:17944362243
VL - 86
SP - 4321
EP - 4325
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 9
ER -