The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes

Anthony G. Comuzzie, M. Elizabeth Tejero, Tohru Funahashi, Lisa J. Martin, Ahmed Kissebah, Masahiko Takahashi, Shinji Kihara, Sachiyo Tanaka, David L. Rainwater, Yuji Matsuzawa, Jean W. Maccluer, John Blangero

    Research output: Contribution to journalArticle

    14 Scopus citations

    Abstract

    Results from previous studies suggest that adiponectin levels are associated with risk factors for cardiovascular disease and type 2 diabetes mellitus; however, the genetic and/or environmental components of this relationship have not been characterized. The aims of this study were (1) to assess the presence of pleiotropy between adiponectin levels and risk factors for cardiovascular disease and (2) to study the association of circulating levels of adiponectin with risk factors for cardiovascular disease in the absence and presence of obesity in Mexican American adults from the San Antonio Family Heart Study. Body composition and circulating levels of adiponectin, leptin, and lipid subfractions and measurements of glucose metabolism were measured in 898 subjects. The mean and standard error of the circulating levels of adiponectin was 8.7 ± 3.2 μg/ml. Bivariate quantitative analyses between adiponectin levels and phenotypes related to cardiovascular disease and type 2 diabetes mellitus were conducted using the variance decomposition approach implemented in SOLAR. A second analysis in unrelated subjects compared these risk factors between sex- and age-matched lean and obese subjects with high and low adiponectin levels. We found significant evidence of pleiotropy (i.e., shared genetic effects) between plasma levels of adiponectin and well-established risk factors for cardiovascular disease and type 2 diabetes mellitus. Individuals with low adiponectin levels per body weight had more adverse risk profiles. These findings offer new insights into the genetic connection between increasing adiposity and risk for cardiovascular disease and type 2 diabetes mellitus, and they suggest that adiponectin may be an important risk factor for the development of these conditions.

    Original languageEnglish (US)
    Pages (from-to)191-200
    Number of pages10
    JournalHuman Biology
    Volume79
    Issue number2
    DOIs
    StatePublished - Apr 2007

    Keywords

    • ACDC (Adipocyte C1Q and Collagen Domain Containing gene)
    • Adiponectin
    • Cardiovascular disease
    • Metabolic syndrome
    • Mexican Americans
    • Obesity
    • Pleiotropy
    • San Antonio Family Heart Study
    • Type 2 diabetes mellitus

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Genetics
    • Genetics(clinical)

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  • Cite this

    Comuzzie, A. G., Tejero, M. E., Funahashi, T., Martin, L. J., Kissebah, A., Takahashi, M., Kihara, S., Tanaka, S., Rainwater, D. L., Matsuzawa, Y., Maccluer, J. W., & Blangero, J. (2007). The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes. Human Biology, 79(2), 191-200. https://doi.org/10.1353/hub.2007.0029