The gene for bone morphogenetic protein 2A (BMP2A) is localized to human chromosome 20pl2 by radioactive and nonradioactive in situ hybridization

V. V.N.Gopal Rao, Christiane Löffler, John M. Wozney, Ingo Hansmann

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Bone morphogenetic protein 2A (BMP2A), a member of the decapentaplegic-Vg-related family, belongs to the transforming growth factor β superfamily and has a striking sequence similarity to the decapentaplegic locus in Drosophila melanogaster, a major determinant of pattern specification during embryogenesis. BMP2A is thought to be involved in cartilage and bone formation during embryogenesis, but may have additional functions in morphogenesis as implied by its expression in various organs and embryonic tissues of mice. Human BMP2A, assigned to chromosome 20 by the use of humanChinese hamster ovary cell hybrids, is considered to be a reasonable candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. We have confirmed the localization of BMP2A to chromosome 20 and regionally assigned the locus to 20pl2 by radioactive and nonradioactive in situ hybridization.

Original languageEnglish (US)
Pages (from-to)299-302
Number of pages4
JournalHuman Genetics
Volume90
Issue number3
DOIs
StatePublished - Nov 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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