The gene fl(2)d is needed for the sex-specific splicing of transformer pre-mRMA but not for double-sex pre-mRNA in Drosophila melanogaster

B. Granadino, L. O.F. Penalva, L. Sánchez

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

In Drosophila melanogaster, regulation of the sex determination genes throughout development occurs by sex-specific splicing of their products. The first gene is Sex-lethal (Sxl). The downstream target of Sxl is the gene transformer (tra): the Sxl protein controls the female-specific splicing of the Tra pre-mRNA. The downstream target of the gene tra is the gene double-sex (dsx): the Tra protein of females, controls the female-specific splicing of the Dsx pre-mRNA. We have identified a gene, female-lethal-2-d fl(2)d, whose function is required for the female-specific splicing of Sxl pre-mRNA. In this report we analyze whether the gene fl(2)d is also required for the sex-specific splicing of both Tra and Dsx pre-mRNAs. We found that the Sxl protein is not sufficient for the female-specific splicing of Tra pre-mRNA, the fl(2)d function also being necessary. This gene, however, is not required for the female-specific splicing of Dsx pre-mRNA.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalMolecular and General Genetics
Volume253
Issue number1-2
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Double-sex
  • Splicing
  • Transformer
  • fl(2)d

ASJC Scopus subject areas

  • Genetics

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