The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER?

Hiten D. Patel; Maneka Puligandla; Brian M. Shuch; Bradley C. Leibovich; Anil Kapoor; Viraj A. Master; Charles G. Drake; Daniel Y.C. Heng; Primo N. Lara; Toni K. Choueiri; Deborah Maskens; Eric A. Singer; Scott E. Eggener; Robert S. Svatek; Walter M. Stadler; Suzanne Cole; Sabina Signoretti; Rajan T. Gupta; Marc Dror Michaelson; David F. McDermott; David Cella; Lynne I. Wagner; Naomi B. Haas; Michael A. Carducci; Lauren C. Harshman; Mohamad E. Allaf

doi:10.2217/fon-2018-0951

The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER?

Hiten D. Patel, Maneka Puligandla, Brian M. Shuch, Bradley C. Leibovich, Anil Kapoor, Viraj A. Master, Charles G. Drake, Daniel Y.C. Heng, Primo N. Lara, Toni K. Choueiri, Deborah Maskens, Eric A. Singer, Scott E. Eggener, Robert S. Svatek, Walter M. Stadler, Suzanne Cole, Sabina Signoretti, Rajan T. Gupta, Marc Dror Michaelson, David F. McDermottDavid Cella, Lynne I. Wagner, Naomi B. Haas, Michael A. Carducci, Lauren C. Harshman, Mohamad E. Allaf

Department of Urology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

While many patients with early stage kidney cancer can be cured by removal of the tumor and kidney ('nephrectomy'), upward of 40% of patients can recur due to microscopic spread of the cancer prior to surgery. Adding anticancer drugs that are effective in the metastatic setting to surgery has potential to eliminate the microscopic disease and increase cure rates. The PROSPER renal cell carcinoma study is testing whether adding nivolumab, a drug that engages the immune system to better recognize, fight and eliminate the cancer, will improve disease control over surgery alone. Nivolumab will be given before and after surgery to see if it reduces the chance of the disease returning and decreases death from kidney cancer compared with patients receiving surgery only.

Original language	English (US)
Pages (from-to)	1683-1695
Number of pages	13
Journal	Future Oncology
Volume	15
Issue number	15
DOIs	https://doi.org/10.2217/fon-2018-0951
State	Published - May 2019

Keywords

PROSPER RCC
clinical trial
kidney cancer
neoadjuvant therapy
nephrectomy
nivolumab
perioperative
presurgical
renal cell carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

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10.2217/fon-2018-0951

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Patel, H. D., Puligandla, M., Shuch, B. M., Leibovich, B. C., Kapoor, A., Master, V. A., Drake, C. G., Heng, D. Y. C., Lara, P. N., Choueiri, T. K., Maskens, D., Singer, E. A., Eggener, S. E., Svatek, R. S., Stadler, W. M., Cole, S., Signoretti, S., Gupta, R. T., Michaelson, M. D., ... Allaf, M. E. (2019). The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER? Future Oncology, 15(15), 1683-1695. https://doi.org/10.2217/fon-2018-0951

Patel, HD, Puligandla, M, Shuch, BM, Leibovich, BC, Kapoor, A, Master, VA, Drake, CG, Heng, DYC, Lara, PN, Choueiri, TK, Maskens, D, Singer, EA, Eggener, SE, Svatek, RS, Stadler, WM, Cole, S, Signoretti, S, Gupta, RT, Michaelson, MD, McDermott, DF, Cella, D, Wagner, LI, Haas, NB, Carducci, MA, Harshman, LC & Allaf, ME 2019, 'The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER?', Future Oncology, vol. 15, no. 15, pp. 1683-1695. https://doi.org/10.2217/fon-2018-0951

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title = "The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER?",

abstract = "While many patients with early stage kidney cancer can be cured by removal of the tumor and kidney ('nephrectomy'), upward of 40% of patients can recur due to microscopic spread of the cancer prior to surgery. Adding anticancer drugs that are effective in the metastatic setting to surgery has potential to eliminate the microscopic disease and increase cure rates. The PROSPER renal cell carcinoma study is testing whether adding nivolumab, a drug that engages the immune system to better recognize, fight and eliminate the cancer, will improve disease control over surgery alone. Nivolumab will be given before and after surgery to see if it reduces the chance of the disease returning and decreases death from kidney cancer compared with patients receiving surgery only.",

keywords = "PROSPER RCC, clinical trial, kidney cancer, neoadjuvant therapy, nephrectomy, nivolumab, perioperative, presurgical, renal cell carcinoma",

author = "Patel, {Hiten D.} and Maneka Puligandla and Shuch, {Brian M.} and Leibovich, {Bradley C.} and Anil Kapoor and Master, {Viraj A.} and Drake, {Charles G.} and Heng, {Daniel Y.C.} and Lara, {Primo N.} and Choueiri, {Toni K.} and Deborah Maskens and Singer, {Eric A.} and Eggener, {Scott E.} and Svatek, {Robert S.} and Stadler, {Walter M.} and Suzanne Cole and Sabina Signoretti and Gupta, {Rajan T.} and Michaelson, {Marc Dror} and McDermott, {David F.} and David Cella and Wagner, {Lynne I.} and Haas, {Naomi B.} and Carducci, {Michael A.} and Harshman, {Lauren C.} and Allaf, {Mohamad E.}",

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year = "2019",

month = may,

doi = "10.2217/fon-2018-0951",

language = "English (US)",

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pages = "1683--1695",

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T1 - The future of perioperative therapy in advanced renal cell carcinoma

T2 - How can we PROSPER?

AU - Patel, Hiten D.

AU - Puligandla, Maneka

AU - Shuch, Brian M.

AU - Leibovich, Bradley C.

AU - Kapoor, Anil

AU - Master, Viraj A.

AU - Drake, Charles G.

AU - Heng, Daniel Y.C.

AU - Lara, Primo N.

AU - Choueiri, Toni K.

AU - Maskens, Deborah

AU - Singer, Eric A.

AU - Eggener, Scott E.

AU - Svatek, Robert S.

AU - Stadler, Walter M.

AU - Cole, Suzanne

AU - Signoretti, Sabina

AU - Gupta, Rajan T.

AU - Michaelson, Marc Dror

AU - McDermott, David F.

AU - Cella, David

AU - Wagner, Lynne I.

AU - Haas, Naomi B.

AU - Carducci, Michael A.

AU - Harshman, Lauren C.

AU - Allaf, Mohamad E.

PY - 2019/5

Y1 - 2019/5

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AB - While many patients with early stage kidney cancer can be cured by removal of the tumor and kidney ('nephrectomy'), upward of 40% of patients can recur due to microscopic spread of the cancer prior to surgery. Adding anticancer drugs that are effective in the metastatic setting to surgery has potential to eliminate the microscopic disease and increase cure rates. The PROSPER renal cell carcinoma study is testing whether adding nivolumab, a drug that engages the immune system to better recognize, fight and eliminate the cancer, will improve disease control over surgery alone. Nivolumab will be given before and after surgery to see if it reduces the chance of the disease returning and decreases death from kidney cancer compared with patients receiving surgery only.

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KW - clinical trial

KW - kidney cancer

KW - neoadjuvant therapy

KW - nephrectomy

KW - nivolumab

KW - perioperative

KW - presurgical

KW - renal cell carcinoma

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The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER?

Abstract

Keywords

ASJC Scopus subject areas

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