The future of animal models of invasive aspergillosis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The diagnosis of invasive aspergillosis remains very difficult, coupled with limited treatment options. Animal models have been utilized to evaluate both the diagnosis and treatment of infection and to assess the pathogenicity and virulence of the organism. However, animal models have not been standardized and have been used in only a limited fashion for genomic evaluation in this disease. Extensive efforts are underway to expand significantly the Aspergillus genomic information. Thus, the standardization of animal models of invasive aspergillosis is critical to create a unified platform to enhance evaluation of newer genomic information and allow assessment of pathogenicity and virulence factors. Proposed models, supported by a recently awarded National Institutes of Health/National Institute of Allergy and Infectious Diseases contract, will be developed in close interaction with the extended Aspergillus community (including academia and industry) to answer key questions in this disease. The goal of this work is to provide the framework to evaluate genomic targets in animal models in order to improve the diagnosis and treatment of invasive aspergillosis that will ultimately result in improved outcomes of patients with this frequently fatal infection.

Original languageEnglish (US)
JournalMedical Mycology
Volume43
Issue numberSUPPL.1
DOIs
StatePublished - 2005

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Aspergillosis
aspergillosis
Animal Models
animal models
genomics
Virulence Factors
Aspergillus
Virulence
virulence
pathogenicity
National Institute of Allergy and Infectious Diseases (U.S.)
National Institutes of Health
National Institutes of Health (U.S.)
Contracts
Infection
standardization
hypersensitivity
infection
infectious diseases
Industry

Keywords

  • Animal models
  • Aspergillus
  • Invasive aspergillosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)
  • Microbiology

Cite this

The future of animal models of invasive aspergillosis. / Patterson, Thomas F.

In: Medical Mycology, Vol. 43, No. SUPPL.1, 2005.

Research output: Contribution to journalArticle

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