The fust stage and complete promoting activity of retinoic acid but not the analog RO-10-9359

Susan M. Fischer, Andres J.P. Klein-szanto, Laurel M. Adams, Thomas J. Slaga

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Abstract

Retinoic acid has the ability to act as either a weak first stage promoter or a weak complete promoter in the initiationpromotion protocol for skin carcinogenesis in the SENCAR mouse. The retinoid analog RO-10-9359 lacks this tumor promoting activity. Both retinoids however inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion. Additional comparisons revealed that retinoic acid alone can induce dark keratinocytes, a characteristic of tumor promoters, while RO-10-9359 cannot. Retinoic acid but not RO-10-9359 can induce an immediate chemiluminescence response in human polymorphonuclear cells. Both retinoids, however, inhibit a TPA-induced response. Since the chemiluminescence response is believed to be due to oxygen free radical generation, the data suggest that the ability of retinoic acid but not RO-10-9359 to promote tumors and induce dark cells may be due to initial oxidative reactions at the cell membrane.

Original languageEnglish (US)
Pages (from-to)575-578
Number of pages4
JournalCarcinogenesis
Volume6
Issue number4
DOIs
StatePublished - Apr 1 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research

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