The function of the secondary site of RecA protein during DNA strand exchange

A. V. Mazin; S. C. Kowalczykowski; Andrzej Stasiak

The function of the secondary site of RecA protein during DNA strand exchange

A. V. Mazin, S. C. Kowalczykowski, Andrzej Stasiak

Research output: Contribution to journal › Review article › peer-review

Abstract

Characterization of the concerned action of the primary and secondary DNA binding site of RecA protein and an elucidation of the role of SSB protein in recombination reactions permitted the authors to clarify existing models of homologous recombination (see Fig. 4). In particular, Mazin and Kowalczykowski established that after DNA strand exchange the displaced strand tends to remain in the secondary DNA binding site of RecA filaments unless it is sequestered by SSB protein. By this activity, SSB protein prevents 'reversal' of DNA strand exchange.

Original language	English (US)
Pages (from-to)	777-784
Number of pages	8
Journal	Chemtracts
Volume	11
Issue number	10
State	Published - Sep 1998
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Biochemistry
Molecular Biology

Cite this

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title = "The function of the secondary site of RecA protein during DNA strand exchange",

abstract = "Characterization of the concerned action of the primary and secondary DNA binding site of RecA protein and an elucidation of the role of SSB protein in recombination reactions permitted the authors to clarify existing models of homologous recombination (see Fig. 4). In particular, Mazin and Kowalczykowski established that after DNA strand exchange the displaced strand tends to remain in the secondary DNA binding site of RecA filaments unless it is sequestered by SSB protein. By this activity, SSB protein prevents 'reversal' of DNA strand exchange.",

author = "Mazin, {A. V.} and Kowalczykowski, {S. C.} and Andrzej Stasiak",

year = "1998",

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journal = "Chemtracts",

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AU - Kowalczykowski, S. C.

AU - Stasiak, Andrzej

PY - 1998/9

Y1 - 1998/9

N2 - Characterization of the concerned action of the primary and secondary DNA binding site of RecA protein and an elucidation of the role of SSB protein in recombination reactions permitted the authors to clarify existing models of homologous recombination (see Fig. 4). In particular, Mazin and Kowalczykowski established that after DNA strand exchange the displaced strand tends to remain in the secondary DNA binding site of RecA filaments unless it is sequestered by SSB protein. By this activity, SSB protein prevents 'reversal' of DNA strand exchange.

AB - Characterization of the concerned action of the primary and secondary DNA binding site of RecA protein and an elucidation of the role of SSB protein in recombination reactions permitted the authors to clarify existing models of homologous recombination (see Fig. 4). In particular, Mazin and Kowalczykowski established that after DNA strand exchange the displaced strand tends to remain in the secondary DNA binding site of RecA filaments unless it is sequestered by SSB protein. By this activity, SSB protein prevents 'reversal' of DNA strand exchange.

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M3 - Review article

AN - SCOPUS:0031761809

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ER -

The function of the secondary site of RecA protein during DNA strand exchange

Abstract

ASJC Scopus subject areas

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