The frequency of glassy cells in Barrett's mucosa: A study in baboons

Carlos A. Rubio, Edward J. Dick, Abiel Orrego, Gene B. Hubbard

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Glands with glassy cells (GGCs) were recently found in 1.8% of patients showing Barrett's mucosa in esophageal biopsies. Similar GGCs were more recently detected in a baboon having glandulo-metaplastic esophageal mucosa (GMEM). The aim was to assess the frequency of baboons with GMEM having GGCs. Materials and Methods: GGCs were sought in 68 consecutive baboons having GMEM. Sections were stained with H&E, and with alcian blue (pH 2.5) to detect sialomucins in goblet cells (a marker of Barrett's mucosa in GMEM). Results: Two out of the 68 baboons with Barrett's mucosa (2.9%) showed GGCs. Conclusion: In similarity to humans, the Barrett's mucosa in baboons may show GGCs. Although the significance of GGCs in baboons (and in humans) remains poorly understood, their presence might not be a fortuitous event but may be linked to the molecular events leading to the development of intestinal metaplasia in Barrett's mucosa, a known pre-neoplastic mucosal change in the distal esophagus in humans.

Original languageEnglish (US)
Pages (from-to)925-927
Number of pages3
JournalIn Vivo
Issue number6
StatePublished - 2009
Externally publishedYes


  • Disease
  • Intestinal metaplasia
  • Nonhuman primate
  • Pathology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology


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