The frequency of gastric pyloric cells with glassy cytoplasm in Baboons. A comparison with human subjects

Carlos A. Rubio, Edward J. Dick, Marian L. Miller, Gene B. Hubbard

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Pyloric cells with "glassy" cytoplasm were detected 20 years ago in the human gastric mucosa, and subsequently in the gastric mucosa of two baboons and of transgenic mice. These pyloric cells, called glassy cells (GCs) show a homogeneous, eosinophilic material that pushes the nucleous towards the free border of the cell. Materials and Methods: The frequency of baboons having pyloric glands with GCs was assessed in the stomachs of 92 consecutive animals, dying of non-gastrointestinal disorders. Results: High power examination of the apparently normal gastric mucosa revealed that 10.9% (n=10) of the 92 baboons had GCs. Periodic acid Schiff (PAS) and PAS-diastase stains suggested that the glassy material might be a glycoprotein. Conclusion: The relatively high frequency of GCs in the gastric mucosa of baboons suggests that this animal might be a useful model for investigating the effect of the environment in the development of GCs, as well as ascertaining the true nature of the retained "glassy" material.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalIn Vivo
Volume22
Issue number1
StatePublished - Jan 1 2008
Externally publishedYes

Keywords

  • Baboons
  • Gastric
  • Glassy cells
  • Humans

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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