TY - JOUR
T1 - The Frequency of Focal Cortical Dysplasia-Like Histologic Features Near Adult-Type Diffuse Gliomas
AU - Bitar, Mireille
AU - Chornenkyy, Yevgen
AU - Flanagan, Margaret E.
AU - Steffens, Alicia
AU - McCortney, Kathleen
AU - Horbinski, Craig
N1 - Publisher Copyright:
© 2021 American Association of Neuropathologists, Inc. All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - While the coexistence of focal cortical dysplasia (FCD) and grade 1 noninfiltrative gliomas has been described, to date, only rare case reports have described FCD adjacent to infiltrating gliomas. We therefore sought to determine how often FCD-like findings occur near adult-type diffuse gliomas. This was a retrospective survey of 186 consecutive, newly diagnosed, en bloc glioma resections. Fifty-nine (31.7%) had sufficient adjacent cortex to evaluate for FCD-like features. Among IDH mutant (“IDHmut”) gliomas, 40/77 (52%) had adjacent evaluable cortex, whereas only 19/109 (17%) of IDH wild-type (“IDHwt”) gliomas did (p < 0.0001). Among cases with evaluable cortex, 15 (25.4%) contained features suggestive of FCD, including radial/tangential dyslamination and/or maloriented neurons. In a multivariable analysis, increasing glioma grade (OR ¼ 4.0, 95% CI ¼ 1.2–13.5, p ¼ 0.027) and IDHmut (OR ¼ 6.5, 95% CI ¼ 1.3–32.2, p ¼ 0.022) emerged as independently positive correlates with the appearance of FCD-like findings. However, FCD-like features were also found in 13/32 (40.6%) cortical samples from adult brains without any neoplastic disease or seizure histories (p ¼ 0.16). Together, these data suggest that, while FCD-like histologic features can be incidentally found in at least a subset of diffusely infiltrative gliomas, the frequencies are not significantly different from that seen in otherwise nonneoplastic brains, and are therefore most likely nonpathologic.
AB - While the coexistence of focal cortical dysplasia (FCD) and grade 1 noninfiltrative gliomas has been described, to date, only rare case reports have described FCD adjacent to infiltrating gliomas. We therefore sought to determine how often FCD-like findings occur near adult-type diffuse gliomas. This was a retrospective survey of 186 consecutive, newly diagnosed, en bloc glioma resections. Fifty-nine (31.7%) had sufficient adjacent cortex to evaluate for FCD-like features. Among IDH mutant (“IDHmut”) gliomas, 40/77 (52%) had adjacent evaluable cortex, whereas only 19/109 (17%) of IDH wild-type (“IDHwt”) gliomas did (p < 0.0001). Among cases with evaluable cortex, 15 (25.4%) contained features suggestive of FCD, including radial/tangential dyslamination and/or maloriented neurons. In a multivariable analysis, increasing glioma grade (OR ¼ 4.0, 95% CI ¼ 1.2–13.5, p ¼ 0.027) and IDHmut (OR ¼ 6.5, 95% CI ¼ 1.3–32.2, p ¼ 0.022) emerged as independently positive correlates with the appearance of FCD-like findings. However, FCD-like features were also found in 13/32 (40.6%) cortical samples from adult brains without any neoplastic disease or seizure histories (p ¼ 0.16). Together, these data suggest that, while FCD-like histologic features can be incidentally found in at least a subset of diffusely infiltrative gliomas, the frequencies are not significantly different from that seen in otherwise nonneoplastic brains, and are therefore most likely nonpathologic.
KW - Focal cortical dysplasia, Glioma
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U2 - 10.1093/jnen/nlab120
DO - 10.1093/jnen/nlab120
M3 - Article
C2 - 35062028
AN - SCOPUS:85123667947
SN - 0022-3069
VL - 81
SP - 48
EP - 53
JO - Journal of Neuropathology and Experimental Neurology
JF - Journal of Neuropathology and Experimental Neurology
IS - 1
ER -