The folate receptor in central nervous system malignancies of childhood

Steven D. Weitman, Karen M. Frazier, Barton A. Kamen

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

The folate receptor is a membrane linked glycoprotein that participates in the cellular accumulation of 5-methyltetrahydrofolic acid, methotrexate and 5,10-dideazatetrahydrofolic acid. Relative receptor overexpression has been observed in several malignant cell lines and tissues. In this study we determined receptor expression using western blot analysis in primary pediatrie malignancies involving the central nervous system. This study suggests that ependymoma tumors have a high frequency of receptor expression which may reflect a specific cytogenetic abnormality or the cellular origin of these tumors. The potential role in developing selective chemotherapy mediated by the folate receptor is also discussed.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalJournal of Neuro-Oncology
Volume21
Issue number2
DOIs
StatePublished - Jun 1994
Externally publishedYes

Keywords

  • antifols
  • brain tumors
  • folate receptor
  • methotrexate

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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