The first recurring chromosome translocation in hepatoblastoma: Der(4)t(1;4)(q12;q34)

Nancy R. Schneider, Linda D. Cooley, Milton J. Finegold, Edwin C. Douglass, Gail E. Tomlinson

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49 Scopus citations


We report four cases of hepatoblastoma with a derivative chromosome 4 from an unbalanced translocation between the long arms of chromosomes 1 and 4, an aberration reported only rarely in isolated cases of other types of neoplasms. The abnormality in three hepatoblastomas was der(4)t(1;4)(q 12;q34), whereas the fourth case appeared to have a der(4)t (q25;q32). All had hyperdiploid tumor karyotypes; however, in the case with t(q25;q32), the der(4) was the only abnormality in the stemline. We speculate that the oncogenetic event in our cases may be the loss of a gene or genes on distal 4q or their alteration by juxtaposition to 1q12 heterochromatin.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalGenes Chromosomes and Cancer
Issue number4
StatePublished - Aug 1997

ASJC Scopus subject areas

  • Genetics
  • Cancer Research


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