The Fifth Saratoga International Conference, Barcelona, Spain, May 18-20 1999: Genomic searches for genes that influence atherosclerosis and its risk factors

James E. Hixson, John Blangero

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used for linkage analysis with variance component methods to identify QTLs for measured phenotypes related to lipid metabolism and atherosclerosis. We conducted such a genomic search in 477 participants of the San Antonio Family Heart Study. This genomic search identified QTLs on chromosomes 3 and 4 that influence LDL size class, an important risk factor of atherosclerosis. In addition to lipid risk factors, we measured a variety of gene products involved in atherogenesis in the arterial wall (such as adhesion molecules and components of hemostasis). We found QTLs for serum levels of soluble P-selectin on chromosome 15 (LOD = 3.8) and chromosome 12 (LOD = 2.6).

    Original languageEnglish (US)
    Pages (from-to)1-7
    Number of pages7
    JournalAnnals of the New York Academy of Sciences
    Volume902
    DOIs
    StatePublished - 2000

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • History and Philosophy of Science

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