TY - JOUR
T1 - The Fifth Saratoga International Conference, Barcelona, Spain, May 18-20 1999
T2 - Genomic searches for genes that influence atherosclerosis and its risk factors
AU - Hixson, James E.
AU - Blangero, John
PY - 2000
Y1 - 2000
N2 - We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used for linkage analysis with variance component methods to identify QTLs for measured phenotypes related to lipid metabolism and atherosclerosis. We conducted such a genomic search in 477 participants of the San Antonio Family Heart Study. This genomic search identified QTLs on chromosomes 3 and 4 that influence LDL size class, an important risk factor of atherosclerosis. In addition to lipid risk factors, we measured a variety of gene products involved in atherogenesis in the arterial wall (such as adhesion molecules and components of hemostasis). We found QTLs for serum levels of soluble P-selectin on chromosome 15 (LOD = 3.8) and chromosome 12 (LOD = 2.6).
AB - We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used for linkage analysis with variance component methods to identify QTLs for measured phenotypes related to lipid metabolism and atherosclerosis. We conducted such a genomic search in 477 participants of the San Antonio Family Heart Study. This genomic search identified QTLs on chromosomes 3 and 4 that influence LDL size class, an important risk factor of atherosclerosis. In addition to lipid risk factors, we measured a variety of gene products involved in atherogenesis in the arterial wall (such as adhesion molecules and components of hemostasis). We found QTLs for serum levels of soluble P-selectin on chromosome 15 (LOD = 3.8) and chromosome 12 (LOD = 2.6).
UR - http://www.scopus.com/inward/record.url?scp=0034045633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034045633&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2000.tb06295.x
DO - 10.1111/j.1749-6632.2000.tb06295.x
M3 - Article
C2 - 10865820
AN - SCOPUS:0034045633
VL - 902
SP - 1
EP - 7
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -