The fibromyalgia family study: A genome-wide linkage scan study

Lesley M. Arnold; Jinbo Fan; I. Jon Russell; Muhammad B. Yunus; Muhammad Asim Khan; Irving Kushner; Sudha K. Iyengar

doi:10.1002/art.37842

The fibromyalgia family study: A genome-wide linkage scan study

Lesley M. Arnold, Jinbo Fan, I. Jon Russell, Muhammad B. Yunus, Muhammad Asim Khan, Irving Kushner, Sudha K. Iyengar

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Objective Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia. Methods We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach. Results The estimated sibling recurrence risk ratio (λ_s) for fibromyalgia was 13.6 (95% confidence interval 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was observed at markers D17S2196 (empirical P [P_e] = 0.00030) and D17S1294 (P_e = 0.00035) on chromosome 17p11.2-q11.2. Conclusion The estimated sibling recurrence risk ratio (λ_s) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.

Original language	English (US)
Pages (from-to)	1122-1128
Number of pages	7
Journal	Arthritis and rheumatism
Volume	65
Issue number	4
DOIs	https://doi.org/10.1002/art.37842
State	Published - Apr 2013
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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title = "The fibromyalgia family study: A genome-wide linkage scan study",

abstract = "Objective Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia. Methods We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach. Results The estimated sibling recurrence risk ratio (λs) for fibromyalgia was 13.6 (95% confidence interval 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was observed at markers D17S2196 (empirical P [Pe] = 0.00030) and D17S1294 (Pe = 0.00035) on chromosome 17p11.2-q11.2. Conclusion The estimated sibling recurrence risk ratio (λs) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.",

author = "Arnold, {Lesley M.} and Jinbo Fan and Russell, {I. Jon} and Yunus, {Muhammad B.} and Khan, {Muhammad Asim} and Irving Kushner and Iyengar, {Sudha K.}",

year = "2013",

month = apr,

doi = "10.1002/art.37842",

language = "English (US)",

volume = "65",

pages = "1122--1128",

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T2 - A genome-wide linkage scan study

AU - Arnold, Lesley M.

AU - Fan, Jinbo

AU - Russell, I. Jon

AU - Yunus, Muhammad B.

AU - Khan, Muhammad Asim

AU - Kushner, Irving

AU - Iyengar, Sudha K.

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N2 - Objective Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia. Methods We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach. Results The estimated sibling recurrence risk ratio (λs) for fibromyalgia was 13.6 (95% confidence interval 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was observed at markers D17S2196 (empirical P [Pe] = 0.00030) and D17S1294 (Pe = 0.00035) on chromosome 17p11.2-q11.2. Conclusion The estimated sibling recurrence risk ratio (λs) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.

AB - Objective Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia. Methods We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach. Results The estimated sibling recurrence risk ratio (λs) for fibromyalgia was 13.6 (95% confidence interval 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was observed at markers D17S2196 (empirical P [Pe] = 0.00030) and D17S1294 (Pe = 0.00035) on chromosome 17p11.2-q11.2. Conclusion The estimated sibling recurrence risk ratio (λs) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.

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The fibromyalgia family study: A genome-wide linkage scan study

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