The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens

You Wen He; Hong Li; Jun Zhang; Chia Lin Hsu; Emily Lin; Nu Zhang; Jian Guo; Katherine A. Forbush; Michael J. Bevan

doi:10.1038/ni1021

The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens

You Wen He, Hong Li, Jun Zhang, Chia Lin Hsu, Emily Lin, Nu Zhang, Jian Guo, Katherine A. Forbush, Michael J. Bevan

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.

Original language	English (US)
Pages (from-to)	88-97
Number of pages	10
Journal	Nature Immunology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/ni1021
State	Published - Jan 2004
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/ni1021

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title = "The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens",

abstract = "Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.",

author = "He, {You Wen} and Hong Li and Jun Zhang and Hsu, {Chia Lin} and Emily Lin and Nu Zhang and Jian Guo and Forbush, {Katherine A.} and Bevan, {Michael J.}",

note = "Funding Information: We thank M. Cook for flow cytometric analysis, and J.R. Wright, L. Hajjar and C.B. Wilson for critically reading this manuscript. This work was supported by National Institutes of Health grant R01 AI54685 (to Y.-W. H.) and the Howard Hughes Medical Institute (to M.J.B.).",

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AU - He, You Wen

AU - Li, Hong

AU - Zhang, Jun

AU - Hsu, Chia Lin

AU - Lin, Emily

AU - Zhang, Nu

AU - Guo, Jian

AU - Forbush, Katherine A.

AU - Bevan, Michael J.

N1 - Funding Information: We thank M. Cook for flow cytometric analysis, and J.R. Wright, L. Hajjar and C.B. Wilson for critically reading this manuscript. This work was supported by National Institutes of Health grant R01 AI54685 (to Y.-W. H.) and the Howard Hughes Medical Institute (to M.J.B.).

PY - 2004/1

Y1 - 2004/1

N2 - Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.

AB - Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.

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The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens

Abstract

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