The expression of granulocyte/macrophage colony-stimulating factor in activated mouse lymphocytes declines with age

Nian Shang Cai, Ding Dong Li, H. Tak Cheung, Arlan Richardson

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) was studied in spleen lymphocytes isolated from male C57BL/6J mice of 6, 20, and 29 months of age. GM-CSF expression (biological activity and mRNA level) was maximum after culturing the lymphocytes for 45 hr with concanavalin A and phorbol myristate acetate. The induction of both GM-CSF activity and mRNA levels was observed to decline over 60% between 6 and 29 months of age. The age-related decline in the level of GM-CSF paralleled the age-related decline in the mRNA levels of interleukin-2 and interleukin-3.

Original languageEnglish (US)
Pages (from-to)311-319
Number of pages9
JournalCellular Immunology
Volume130
Issue number2
DOIs
StatePublished - Oct 15 1990

ASJC Scopus subject areas

  • Immunology

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