Abstract
The expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) was studied in spleen lymphocytes isolated from male C57BL/6J mice of 6, 20, and 29 months of age. GM-CSF expression (biological activity and mRNA level) was maximum after culturing the lymphocytes for 45 hr with concanavalin A and phorbol myristate acetate. The induction of both GM-CSF activity and mRNA levels was observed to decline over 60% between 6 and 29 months of age. The age-related decline in the level of GM-CSF paralleled the age-related decline in the mRNA levels of interleukin-2 and interleukin-3.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 311-319 |
| Number of pages | 9 |
| Journal | Cellular Immunology |
| Volume | 130 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 15 1990 |
ASJC Scopus subject areas
- Immunology
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Cai, N. S., Li, D. D., Cheung, H. T., & Richardson, A. (1990). The expression of granulocyte/macrophage colony-stimulating factor in activated mouse lymphocytes declines with age. Cellular Immunology, 130(2), 311-319. https://doi.org/10.1016/0008-8749(90)90274-U