The etiology of lenticulostriate vasculopathy and the role of congenital infections

Joseph B. Cantey, Julide Sisman

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Lenticulostriate vasculopathy (LSV) refers to increased echogenicity of the penetrating vessels that supply the basal ganglia and segments of the internal capsule seen on cranial ultrasound. Initially identified in infants with congenital infection, LSV has now been associated with a variety of infectious and non-infectious conditions. Although robust epidemiologic studies are lacking, the available evidence does not support broad evaluation for multiple congenital infections when LSV is identified. We propose screening infants with LSV for congenital cytomegalovirus infection and ensuring that prenatal screening included appropriate testing for syphilis, human immunodeficiency virus, and rubella-immune status. Large, prospective observational studies are needed to determine the incidence of LSV and the relative contribution of infectious and non-infectious conditions to LSV in the neonate.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalEarly Human Development
Issue number7
StatePublished - Jul 1 2015
Externally publishedYes


  • Cytomegalovirus
  • Infection
  • Ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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