The estimation of elimination rates of persistent compounds: A re- analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans

G. W. Van Der Molen; S. A.L.M. Kooijman; J. E. Michalek; W. Slob

doi:10.1016/S0045-6535(98)00249-5

The estimation of elimination rates of persistent compounds: A re- analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans

G. W. Van Der Molen, S. A.L.M. Kooijman, J. E. Michalek, W. Slob

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The elimination rate of TCDD was re-estimated from measurements of internal concentrations in Vietnam veterans with a model that can account for age dependent body composition, and both age and (calender) time dependent background intake. Estimates of the specific elimination rate, which is independent of body composition, did not differ much between fits with different simplifications of this model for this particular data set. However, the assumption that the associated half-life is constant over the human lifespan is improper. The overall elimination rate and half-life are only constant when background intake and body composition are approximately constant. For example, our model predicts that half-life ranges between 5.5 in young adults and 11 years in elderly men. The change of half-life with age should be accounted for in toxicokinetic calculations.

Original language	English (US)
Pages (from-to)	1833-1844
Number of pages	12
Journal	Chemosphere
Volume	37
Issue number	9-12
DOIs	https://doi.org/10.1016/S0045-6535(98)00249-5
State	Published - Oct 1998

ASJC Scopus subject areas

General Chemistry
Public Health, Environmental and Occupational Health
Pollution
Health, Toxicology and Mutagenesis
Environmental Engineering
Environmental Chemistry

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10.1016/S0045-6535(98)00249-5

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abstract = "The elimination rate of TCDD was re-estimated from measurements of internal concentrations in Vietnam veterans with a model that can account for age dependent body composition, and both age and (calender) time dependent background intake. Estimates of the specific elimination rate, which is independent of body composition, did not differ much between fits with different simplifications of this model for this particular data set. However, the assumption that the associated half-life is constant over the human lifespan is improper. The overall elimination rate and half-life are only constant when background intake and body composition are approximately constant. For example, our model predicts that half-life ranges between 5.5 in young adults and 11 years in elderly men. The change of half-life with age should be accounted for in toxicokinetic calculations.",

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AB - The elimination rate of TCDD was re-estimated from measurements of internal concentrations in Vietnam veterans with a model that can account for age dependent body composition, and both age and (calender) time dependent background intake. Estimates of the specific elimination rate, which is independent of body composition, did not differ much between fits with different simplifications of this model for this particular data set. However, the assumption that the associated half-life is constant over the human lifespan is improper. The overall elimination rate and half-life are only constant when background intake and body composition are approximately constant. For example, our model predicts that half-life ranges between 5.5 in young adults and 11 years in elderly men. The change of half-life with age should be accounted for in toxicokinetic calculations.

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The estimation of elimination rates of persistent compounds: A re- analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans

Abstract

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