The epsin 4 gene is associated with psychotic disorders in families of Latin American origin

Michael Escamilla, Byung Dae Lee, Alfonso Ontiveros, Henriette Raventos, Humberto Nicolini, Ricardo Mendoza, Alvaro Jerez, Rodrigo Munoz, Rolando Medina, Andres Figueroa, Consuelo Walss-Bass, Regina Armas, Salvador Contreras, Mercedes E. Ramirez, Albana Dassori

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia drawn from the Latin American population. 1423 subjects (767 with a history of psychosis) from 337 Latino families were genotyped using three single nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test was utilized to test for association of these SNPs to the phenotypes of psychosis and schizophrenia. Haplotypes defined by these three SNPs showed significant association to the phenotype of psychosis in this sample (global p value = 0.014, bi-allelic p value = 0.047). Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population. This provides additional support for the involvement of enthoprotin in the pathogenesis of schizophrenia and other psychotic disorders.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalSchizophrenia research
Volume106
Issue number2-3
DOIs
StatePublished - Dec 2008

Keywords

  • Biobehavioral Science
  • Epsin 4 gene
  • Phenotype
  • Schizophrenia
  • Single nucleotide polymorphisms (SNPs)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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