Abstract
This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia drawn from the Latin American population. 1423 subjects (767 with a history of psychosis) from 337 Latino families were genotyped using three single nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test was utilized to test for association of these SNPs to the phenotypes of psychosis and schizophrenia. Haplotypes defined by these three SNPs showed significant association to the phenotype of psychosis in this sample (global p value = 0.014, bi-allelic p value = 0.047). Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population. This provides additional support for the involvement of enthoprotin in the pathogenesis of schizophrenia and other psychotic disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 253-257 |
| Number of pages | 5 |
| Journal | Schizophrenia Research |
| Volume | 106 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Dec 2008 |
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Keywords
- Biobehavioral Science
- Epsin 4 gene
- Phenotype
- Schizophrenia
- Single nucleotide polymorphisms (SNPs)
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
The epsin 4 gene is associated with psychotic disorders in families of Latin American origin. / Escamilla, Michael; Lee, Byung Dae; Ontiveros, Alfonso; Raventos, Henriette; Nicolini, Humberto; Mendoza, Ricardo; Jerez, Alvaro; Munoz, Rodrigo; Medina, Rolando; Figueroa, Andres; Walss-Bass, Consuelo; Armas, Regina; Contreras, Salvador; Ramirez, Mercedes E.; Dassori, Albana M.
In: Schizophrenia Research, Vol. 106, No. 2-3, 12.2008, p. 253-257.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The epsin 4 gene is associated with psychotic disorders in families of Latin American origin
AU - Escamilla, Michael
AU - Lee, Byung Dae
AU - Ontiveros, Alfonso
AU - Raventos, Henriette
AU - Nicolini, Humberto
AU - Mendoza, Ricardo
AU - Jerez, Alvaro
AU - Munoz, Rodrigo
AU - Medina, Rolando
AU - Figueroa, Andres
AU - Walss-Bass, Consuelo
AU - Armas, Regina
AU - Contreras, Salvador
AU - Ramirez, Mercedes E.
AU - Dassori, Albana M
PY - 2008/12
Y1 - 2008/12
N2 - This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia drawn from the Latin American population. 1423 subjects (767 with a history of psychosis) from 337 Latino families were genotyped using three single nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test was utilized to test for association of these SNPs to the phenotypes of psychosis and schizophrenia. Haplotypes defined by these three SNPs showed significant association to the phenotype of psychosis in this sample (global p value = 0.014, bi-allelic p value = 0.047). Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population. This provides additional support for the involvement of enthoprotin in the pathogenesis of schizophrenia and other psychotic disorders.
AB - This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia drawn from the Latin American population. 1423 subjects (767 with a history of psychosis) from 337 Latino families were genotyped using three single nucleotide polymorphisms (SNPs) spanning the Epsin 4 gene. A family based association test was utilized to test for association of these SNPs to the phenotypes of psychosis and schizophrenia. Haplotypes defined by these three SNPs showed significant association to the phenotype of psychosis in this sample (global p value = 0.014, bi-allelic p value = 0.047). Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population. This provides additional support for the involvement of enthoprotin in the pathogenesis of schizophrenia and other psychotic disorders.
KW - Biobehavioral Science
KW - Epsin 4 gene
KW - Phenotype
KW - Schizophrenia
KW - Single nucleotide polymorphisms (SNPs)
UR - http://www.scopus.com/inward/record.url?scp=56049088477&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56049088477&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2008.09.005
DO - 10.1016/j.schres.2008.09.005
M3 - Article
C2 - 18929466
AN - SCOPUS:56049088477
VL - 106
SP - 253
EP - 257
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -